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AB204493

Anti-AIF1L antibody

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(2 Publications)

Rabbit Polyclonal AIF1L antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AIF1L aa 1-50.

View Alternative Names

C9orf58, IBA2, UNQ672/PRO1306, AIF1L, Allograft inflammatory factor 1-like, Ionized calcium-binding adapter molecule 2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIF1L antibody (AB204493)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIF1L antibody (AB204493)

Immunohistochemistry analysis of paraffin-embedded human kidney tissue labeling AIF1L with ab204493 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AIF1L aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9BQI0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AIF1L also known as Allograft Inflammatory Factor 1-like is a protein with a molecular weight of approximately 17 kDa. It's mainly expressed in activated macrophages and microglia. AIF1L is also detected in several other tissues such as the spleen pancreas and small intestine. In cells it localizes to the cytoplasm and sometimes the nucleus contributing to cytoskeletal organization.
Biological function summary

The protein functions in immune response modulation and cellular activation processes. It does not form part of a known protein complex but it contributes significantly to actin cytoskeleton rearrangement suggesting a role in cell migration and phagocytosis. AIF1L influences inflammatory responses by modulating macrophage activity which is important for tissue injury response and repair processes.

Pathways

AIF1L interacts with cytoskeletal signaling pathways and immune system pathways. AIF1L's role in actin rearrangement links it to pathways involved in cellular motility and structural integrity. Its modulation of inflammation connects it to pathway interactions with other proteins like actin-binding proteins and cytokines influencing immune system regulation and macrophage activation.

AIF1L holds relevance to autoimmunity and atherosclerosis where immune response regulation is disrupted. In autoimmune conditions the dysregulation of pathways involving AIF1L can exacerbate immune cell activation and inflammation. In atherosclerosis its function in macrophage activation intersects with proteins like CD68 contributing to foam cell formation and plaque buildup in arterial walls advancing our understanding of inflammatory processes in cardiovascular diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.
See full target information AIF1L
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1586784 PubMed40861463

2025

The value of nucleoporin 188 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to gastric cancer verification.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengfeng Zhu,Ru Peng,Huanhuan Cai

Cell reports. Medicine 4:101277 PubMed37944531

2023

Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxue Ren,Mingle Huang,Weixiang Weng,Yubin Xie,Yifan Wu,Shenghua Zhu,Ying Zhang,Dongming Li,Jiaming Lai,Shunli Shen,Jie Lin,Ming Kuang,Xiaoxing Li,Jun Yu,Lixia Xu
View all publications
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Product promise

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