Skip to main content

Rabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Beta/gamma crystallin domain-containing protein 1 aa 700-850.

Be the first to review this product! Submit a review

Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIM1 antibody (AB204846), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-AIM1 antibody (AB204846), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Beta/gamma crystallin domain-containing protein 1 aa 700-850. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y4K1

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC/IF
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/200.00000 - 1/500.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Tested
Tested

Species

Human

Dilution info

0.25000-2.00000 µg/mL

Notes

-

Target data

Function

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

Alternative names

Recommended products

Rabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Beta/gamma crystallin domain-containing protein 1 aa 700-850.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Beta/gamma crystallin domain-containing protein 1 aa 700-850. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y4K1
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The AIM1 protein also known as Absent In Melanoma 1 has roles in various cellular processes. It is commonly identified in multiple tissues including the skin and the eyes where it contributes to cellular stability and function. AIM1 has a molecular mass of around 69 kilodaltons. Its expression patterns suggest it plays significant roles in cellular microenvironment and differentiation especially in melanocytes and ocular cells. Expression levels may vary affecting cellular activities accordingly.

Biological function summary

AIM1 associates with structures that include the cytoskeleton indicating its potential role in maintaining cell shape and motility. It has binding capabilities that aid in cellular assembly processes. AIM1 does not usually operate as part of a larger protein complex but influences intracellular signaling indirectly. Its involvement in cell stability further implies a role in developmental pathways possibly impacting cellular proliferation and differentiation outcomes in melanocytes.

Pathways

AIM1 interacts with signaling pathways related to cellular differentiation and proliferation. It plays a part in the regulation of actin cytoskeleton pathways where it influences cellular architecture and movement. In these pathways proteins like Rho family GTPases may relate to AIM1 impacting downstream signaling events. Such interactions highlight AIM1’s influence on dynamic cellular changes and stability.

Associated diseases and disorders

AIM1 shows links to melanoma and retinal diseases. In melanoma AIM1 expression often changes suggesting it may contribute to the aggressive behavior of melanocytes when dysregulated. Connections to ocular proteins like CRX suggest that AIM1 may also play a part in some retinal degenerative conditions. The protein's influence on cellular structure and signaling makes it a significant target for understanding and potentially treating these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIM1 antibody (ab204846), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIM1 antibody (ab204846)

    Immunohistochemical analysis of formalin fixed, paraffin embedded Human esophagus tissue labeling AIM1 with ab204846 at 1/200 dilution.

  • Immunocytochemistry/ Immunofluorescence - Anti-AIM1 antibody (ab204846), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-AIM1 antibody (ab204846)

    Immunofluorescent analysis of PFA/Triton X-100 fixed and permeabilized A-431 cells labeling AIM1 with ab204846 at 4 μg/ml. Antibody staining is shown in green.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com