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AB204846

Anti-AIM1 antibody

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(1 Publication)

Rabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CRYBG1 aa 700-850.

View Alternative Names

AIM1, CRYBG1, Beta/gamma crystallin domain-containing protein 1, Absent in melanoma 1 protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-AIM1 antibody (AB204846)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AIM1 antibody (AB204846)

Immunofluorescent analysis of PFA/Triton X-100 fixed and permeabilized A-431 cells labeling AIM1 with ab204846 at 4 μg/ml. Antibody staining is shown in green.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIM1 antibody (AB204846)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIM1 antibody (AB204846)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human esophagus tissue labeling AIM1 with ab204846 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CRYBG1 aa 700-850. The exact immunogen used to generate this antibody is proprietary information.

Q9Y4K1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AIM1 protein also known as Absent In Melanoma 1 has roles in various cellular processes. It is commonly identified in multiple tissues including the skin and the eyes where it contributes to cellular stability and function. AIM1 has a molecular mass of around 69 kilodaltons. Its expression patterns suggest it plays significant roles in cellular microenvironment and differentiation especially in melanocytes and ocular cells. Expression levels may vary affecting cellular activities accordingly.
Biological function summary

AIM1 associates with structures that include the cytoskeleton indicating its potential role in maintaining cell shape and motility. It has binding capabilities that aid in cellular assembly processes. AIM1 does not usually operate as part of a larger protein complex but influences intracellular signaling indirectly. Its involvement in cell stability further implies a role in developmental pathways possibly impacting cellular proliferation and differentiation outcomes in melanocytes.

Pathways

AIM1 interacts with signaling pathways related to cellular differentiation and proliferation. It plays a part in the regulation of actin cytoskeleton pathways where it influences cellular architecture and movement. In these pathways proteins like Rho family GTPases may relate to AIM1 impacting downstream signaling events. Such interactions highlight AIM1’s influence on dynamic cellular changes and stability.

AIM1 shows links to melanoma and retinal diseases. In melanoma AIM1 expression often changes suggesting it may contribute to the aggressive behavior of melanocytes when dysregulated. Connections to ocular proteins like CRX suggest that AIM1 may also play a part in some retinal degenerative conditions. The protein's influence on cellular structure and signaling makes it a significant target for understanding and potentially treating these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.
See full target information CRYBG1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in endocrinology 12:727915 PubMed34526970

2021

Upregulation of in Diet-Induced Obesity Mouse and the Hypothalamic Appetite Control.

Applications

Unspecified application

Species

Unspecified reactive species

Dongxiao Zhang,Satoshi Yamaguchi,Xinhao Zhang,Boxuan Yang,Naoko Kurooka,Ryosuke Sugawara,Haya Hamed H Albuayjan,Atsuko Nakatsuka,Jun Eguchi,Takeshi Y Hiyama,Atsunori Kamiya,Jun Wada
View all publications
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Product promise

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