Rabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Beta/gamma crystallin domain-containing protein 1 aa 700-850.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.
AIM1, CRYBG1, AIM1, Beta/gamma crystallin domain-containing protein 1, Absent in melanoma 1 protein
Rabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Beta/gamma crystallin domain-containing protein 1 aa 700-850.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The AIM1 protein also known as Absent In Melanoma 1 has roles in various cellular processes. It is commonly identified in multiple tissues including the skin and the eyes where it contributes to cellular stability and function. AIM1 has a molecular mass of around 69 kilodaltons. Its expression patterns suggest it plays significant roles in cellular microenvironment and differentiation especially in melanocytes and ocular cells. Expression levels may vary affecting cellular activities accordingly.
AIM1 associates with structures that include the cytoskeleton indicating its potential role in maintaining cell shape and motility. It has binding capabilities that aid in cellular assembly processes. AIM1 does not usually operate as part of a larger protein complex but influences intracellular signaling indirectly. Its involvement in cell stability further implies a role in developmental pathways possibly impacting cellular proliferation and differentiation outcomes in melanocytes.
AIM1 interacts with signaling pathways related to cellular differentiation and proliferation. It plays a part in the regulation of actin cytoskeleton pathways where it influences cellular architecture and movement. In these pathways proteins like Rho family GTPases may relate to AIM1 impacting downstream signaling events. Such interactions highlight AIM1’s influence on dynamic cellular changes and stability.
AIM1 shows links to melanoma and retinal diseases. In melanoma AIM1 expression often changes suggesting it may contribute to the aggressive behavior of melanocytes when dysregulated. Connections to ocular proteins like CRX suggest that AIM1 may also play a part in some retinal degenerative conditions. The protein's influence on cellular structure and signaling makes it a significant target for understanding and potentially treating these conditions.
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Immunohistochemical analysis of formalin fixed, paraffin embedded Human esophagus tissue labeling AIM1 with ab204846 at 1/200 dilution.
Immunofluorescent analysis of PFA/Triton X-100 fixed and permeabilized A-431 cells labeling AIM1 with ab204846 at 4 μg/ml. Antibody staining is shown in green.
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