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AB67471

Anti-AIMP2/p38 antibody

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(1 Publication)

Mouse Polyclonal AIMP2/p38 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human AIMP2.

View Alternative Names

JTV1, PRO0992, AIMP2, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1

1 Images
Western blot - Anti-AIMP2/p38 antibody (AB67471)
  • WB

Unknown

Western blot - Anti-AIMP2/p38 antibody (AB67471)

All lanes:

Western blot - Anti-AIMP2/p38 antibody (ab67471) at 1/500 dilution

Lane 1:

AIMP2/p38 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 35 kDa

Observed band size: 35 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human AIMP2.

Q13155

Specificity

This antibody is reactive against mammalian transfected lysate.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AIMP2 also known as p38 is a multifunctional protein involved in several cellular processes. Measuring at a molecular weight of approximately 52 kDa AIMP2 plays an important role in regulating protein synthesis as a part of the aminoacyl-tRNA synthetase complex. This protein is widely expressed throughout various tissues in the body including lung liver and brain indicating its importance across different physiological contexts.
Biological function summary

AIMP2 acts as a scaffolding protein integrating signals between the aminoacyl-tRNA synthetase complex and other cellular mechanisms. It forms a complex with several components in the multi-aminoacyl-tRNA synthetase complex aiding in protein translation. The protein is involved in the maintenance of cellular homeostasis and stress responses by modulating protein synthesis and degradation processes.

Pathways

Multiple studies have shown that AIMP2 integrates into several important signaling pathways like the p53 pathway. AIMP2 enhances the activation of p53 tumor suppressor protein facilitating cellular responses to DNA damage and oxidative stress. It interacts closely with proteins like MDM2 mediating p53 stability and activity linking AIMP2 to cellular growth control and apoptosis regulation.

Mutations or dysregulation of AIMP2 have been connected to various conditions including neurodegenerative diseases and cancer. For example alterations in AIMP2 expression levels are implicated in Parkinson’s disease where its role in dopaminergic neuron survival is compromised. In cancer AIMP2 interacts with proteins like FBP1 affecting tumor progression and metastasis making it an important target for therapeutic interventions in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed : 19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
See full target information AIMP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular neurobiology 55:370-381 PubMed28004338

2016

Network Analysis Identifies Disease-Specific Pathways for Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara Monti,Ilaria Colugnat,Leonardo Lopiano,Adriano Chiò,Tiziana Alberio
View all publications
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Product promise

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