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AB228684

Anti-AIP antibody

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(1 Publication)

Rabbit Polyclonal AIP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AIP.

View Alternative Names

XAP2, AIP, AH receptor-interacting protein, Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, Immunophilin homolog ARA9, XAP-2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-AIP antibody (AB228684)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AIP antibody (AB228684)

4% paraformaldehyde-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for AIP (green) using ab228684 at 1/500 dilution in ICC/IF.

Nuclear counterstain : Hoechst 33342 (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIP antibody (AB228684)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIP antibody (AB228684)

Paraffin-embedded mouse middle brain tissue stained for AIP using ab228684 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human AIP. The exact immunogen used to generate this antibody is proprietary information.

O00170

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AIP also known as aryl hydrocarbon receptor-interacting protein is a molecular chaperone with a mass of approximately 37 kDa. It mainly resides in the cytoplasm of cells and interacts with various proteins. Expression of the AIP protein occurs in many tissues including liver lung and brain. This protein plays a significant role in maintaining the stability and proper functioning of its interacting partners.
Biological function summary

AIP acts as a modulator of protein-protein interactions impacting several signaling pathways. It is a part of the larger protein complex involving heat shock proteins which helps prevent the degradation of its client proteins. AIP is essential for the activity and stability of receptors like the aryl hydrocarbon receptor (AHR) helping these receptors remain in a functional state until they get activated.

Pathways

AIP incorporates itself into the AHR signaling pathway which affects the regulation of xenobiotic metabolism. The protein is also involved in the regulation of the glucocorticoid receptor pathway working closely with proteins like Hsp90. Through these interactions AIP influences the ability of cells to respond to environmental toxins and physiological stress thereby playing a role in cellular homeostasis.

AIP has a connection with familial isolated pituitary adenomas (FIPA) and is also implicated in some forms of cancer. AIP mutations can lead to alterations in the function of the AHR receptor which is linked to these conditions. A notable interaction partner of AIP in these contexts is the pituitary tumor transforming gene (PTTG) which highlights its role in tumorigenesis and the regulation of cell proliferation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.. Cellular negative regulator of the hepatitis B virus (HBV) X protein.
See full target information AIP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2221 PubMed40082403

2025

PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Ono,Yoshitaka Taketomi,Takayoshi Higashi,Hiroyasu Sato,Chika Mochizuki-Ono,Yuki Nagasaki,Takashi Ueta,Takashi Miyai,Suzumi M Tokuoka,Yoshiya Oda,Yasumasa Nishito,Tomio Ono,Choji Taya,Satoru Arata,Sumiko Watanabe,Tomoyoshi Soga,Tetsuya Hirabayashi,Makoto Aihara,Makoto Murakami
View all publications
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Product promise

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