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AB238688

Anti-AIP1 antibody

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(1 Publication)

Rabbit Polyclonal AIP1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAGI2 aa 1300 to C-terminus.

View Alternative Names

ACVRINP1, AIP1, KIAA0705, MAGI2, Atrophin-1-interacting protein 1, Atrophin-1-interacting protein A, Membrane-associated guanylate kinase inverted 2, AIP-1, MAGI-2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-AIP1 antibody (AB238688)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AIP1 antibody (AB238688)

A549 (human lung carcinoma cell line) cells stained for AIP1 (green) using ab238688 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIP1 antibody (AB238688)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIP1 antibody (AB238688)

Paraffin-embedded human brain tissue stained for AIP1 using ab238688 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MAGI2 aa 1300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q86UL8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AIP1 also known as ASK1-interacting protein-1 is a multifunctional protein involved in the regulation of apoptosis and inflammation. It possesses a mass of approximately 90 kDa and is widely expressed in various tissues including the heart lung liver and skeletal muscle. This protein plays an important role in cell signaling pathways serving as an adapter protein in stress-related pathways. It binds to and regulates the function of apoptosis signal-regulating kinase 1 (ASK1) influencing cellular stress responses and survival decisions.
Biological function summary

The actions of AIP1 extend beyond simple interaction with ASK1. AIP1 is involved in the modulation of inflammatory processes and oxidative stress impacting cell damage and repair. It functions as a part of a complex signaling network where it influences cellular responses to external stress by interacting with other proteins. Its interaction with signaling molecules modulates pathways that control apoptosis making it an important regulator of cell fate.

Pathways

AIP1 is engaged in the MAPK signaling and JNK pathways where it regulates responses to cellular stress and apoptosis. AIP1 interacts significantly with proteins like tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) which are critical in these pathways. Through these interactions AIP1 influences the balance between cell death and survival under stress conditions contributing to cellular homeostasis.

The involvement of AIP1 in apoptosis and inflammation links it to conditions such as cancer and cardiovascular disease. Its regulation of stress-response pathways implicates alterations in AIP1 function with the progression of these diseases. For instance abnormal expression of AIP1 can impact the regulatory role of ASK1 in cancerous cell survival. Furthermore dysregulated AIP1 activity might disrupt normal apoptotic processes and exacerbate inflammatory responses contributing to cardiovascular pathology through interactions with related proteins such as TRAF2.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (PubMed : 10760291). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity).
See full target information MAGI2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 23:175 PubMed35497935

2022

KLF10 upregulates ACSM3 via the PI3K/Akt signaling pathway to inhibit the malignant progression of melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhirong Zhao,Yuanchang Zhan,Li Jing,Huali Zhai
View all publications
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Product promise

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