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AB85132

Anti-AK5 antibody

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(1 Publication)

Rabbit Polyclonal AK5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Adenylate kinase isoenzyme 5.

View Alternative Names

Adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5, AK5

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AK5 antibody (AB85132)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AK5 antibody (AB85132)

Immunohistochemical staining of formalin-fixed paraffin-embedded brain showing cytoplasmic staining with ab85132 at 1 : 100 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Adenylate kinase isoenzyme 5. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6K8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.02% Sodium azide Constituents: 2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AK5 or Adenylate Kinase 5 is an enzyme with a specialized role in phosphate group transfer. It functions by catalyzing the reversible transfer of phosphate groups from ATP to AMP which results in the production of ADP. The enzyme has a molecular mass of approximately 26 kDa. AK5 typically shows expression in the brain where it can significantly influence energy transfer and cellular energy balance.
Biological function summary

The function of AK5 involves maintaining energy homeostasis in neural cells. It does not act independently; rather it functions as a part of a larger complex that regulates cellular energetic states. In neural tissues AK5 may have substantial impacts on cellular activity by controlling the levels of key adenylates therefore influencing intracellular signaling pathways.

Pathways

AK5 plays a part in the cellular energy homeostasis pathway and is integral to the purine metabolism pathway. In these pathways AK5 interacts with other adenylate kinases and has associations with enzymes such as AMP-activated protein kinase (AMPK) which acts as an energy sensor. AK5's role in these pathways helps to maintain the balance of adenine nucleotides critical for cellular functions.

Abnormalities in AK5 expression or function can be associated with neurological conditions such as epilepsy. AK5's connection with epilepsy relates partly through its involvement in maintaining proper cellular energetic conditions critical for normal neural activity. It may also relate to metabolic disorders because changes in adenylate kinase function can impact metabolic regulation in the brain. AK5's relationship with AMPK hints at how it might link to these conditions given AMPK's role in detecting cellular energy levels.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.
See full target information Adenylate kinase isoenzyme 5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 128:3129-3143 PubMed29715200

2018

TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Ramesh Singh,Dileep Karri,Hong Shen,Jiangyong Shao,Subhamoy Dasgupta,Shixia Huang,Dean P Edwards,Michael M Ittmann,Bert W O'Malley,Ping Yi
View all publications
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Product promise

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