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AB77075

Anti-AKIRIN1 antibody

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(1 Publication)

Rabbit Polyclonal AKIRIN1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AKIRIN1.

View Alternative Names

C1orf108, AKIRIN1, Akirin-1

1 Images
Western blot - Anti-AKIRIN1 antibody (AB77075)
  • WB

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Western blot - Anti-AKIRIN1 antibody (AB77075)

Lane 1:

Western blot - Anti-AKIRIN1 antibody (ab77075) at 1 µg/mL

Lane 2:

Western blot - Anti-AKIRIN1 antibody (ab77075) at 2 µg/mL

All lanes:

A549 cell lysate at 15 µg

Predicted band size: 22 kDa

Observed band size: 27 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human AKIRIN1. The exact immunogen used to generate this antibody is proprietary information.

Q9H9L7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AKIRIN1 also known as Akirin or AKIRIN serves as an important protein involved in regulating gene expression during immune response. This protein has a molecular weight of approximately 20 kDa. AKIRIN1 is most commonly observed in tissues such as the brain heart testis and placenta and it is also present in cells of the immune system. AKIRIN1 does not act independently; it coordinates with other proteins to carry out its functions.
Biological function summary

AKIRIN1 plays a role in transcriptional regulation by facilitating the activation of specific genes linked to immune and stress responses. It is not a solitary player; instead it associates with nuclear factors forming part of a transcriptional complex. This complex interaction allows AKIRIN1 to participate in controlling inflammation by regulating the expression of genes that mediate immune response. Its precise function in transcription regulation highlights its significance in cellular response mechanisms.

Pathways

AKIRIN1 interacts with various proteins to influence essential signaling pathways like the NF-kB signaling pathway and the Toll-like receptor (TLR) pathway. It associates with proteins such as MyD88 and IRAK4 which are important in propagating signals that lead to the activation of NF-kB. This interaction places AKIRIN1 as an important player in pathways that lead to inflammatory responses demonstrating its involvement in translating extracellular signals into nuclear responses.

AKIRIN1 has been implicated in conditions such as autoimmune disorders and inflammatory diseases. Specifically its involvement in the regulation of the NF-kB pathway links it to disorders like rheumatoid arthritis where dysregulation of this pathway contributes to chronic inflammation. Proteins such as TNF-alpha are also connected to AKIRIN1 through these disorders further emphasizing its role in disease progression and the immune response.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (PubMed : 34711951).
See full target information AKIRIN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta physiologica (Oxford, England) 211:617-33 PubMed24938737

2014

Impaired structural and functional regeneration of skeletal muscles from β2-adrenoceptor knockout mice.

Applications

WB

Species

Unspecified reactive species

M T Silva,L A Wensing,P C Brum,N O Câmara,E H Miyabara
View all publications
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Product promise

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