Anti-AKR7A3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

AKR7A3 also known as aflatoxin aldehyde reductase is an enzyme that functions mechanically to reduce aldehyde substrates to alcohols. This protein weighs approximately 36 kDa and is expressed widely in human tissues with higher levels in the liver and kidneys. AKR7A3 belongs to the aldo-keto reductase superfamily which is involved in detoxifying reactive carbonyl species playing an important role in protecting cells from oxidative stress.

Biological function summary

The detoxifying enzyme AKR7A3 significantly contributes to cellular defense mechanisms by converting toxic aldehydes such as those from lipid peroxidation into less harmful alcohols. It does not commonly form part of any protein complex but interacts indirectly with other detoxification enzymes to maintain cellular redox balance. Its activity supports cell survival under conditions of oxidative stress by mitigating the damaging effects of reactive aldehyde intermediates.

Pathways

AKR7A3 is instrumental in the metabolism of xenobiotics and the inflammatory response pathways. It plays a role in pathways alongside enzymes like glutathione S-transferase contributing to the detoxification of electrophiles and reactive aldehydes. This protective action reduces cellular oxidative stress functioning in tandem with enzymes involved in glutathione metabolism to safeguard cellular components from damage.

Associated diseases and disorders

AKR7A3 has associations with liver pathologies including hepatocellular carcinoma and metabolic disorders involving oxidative stress. It shares a connection with proteins like Nrf2 which regulates the expression of antioxidant proteins and contributes to the cellular response against oxidative damage. Altered expression or function of AKR7A3 can impact the detoxification processes potentially leading to increased susceptibility to liver disease and cancer development.