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AB182893

Anti-Aldehyde Dehydrogenase antibody

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(3 Publications)

Rabbit Polyclonal ALDHY antibody. Suitable for WB, IF and reacts with Saccharomyces cerevisiae samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Saccharomyces cerevisiae ALD1.

View Alternative Names

ALDH2, ALD2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Saccharomyces cerevisiae

Applications

IF, WB

applications

Immunogen

Native Full Length Protein corresponding to Saccharomyces cerevisiae ALD1.

P22281

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IF" : {"fullname" : "Immunofluorescence", "shortname":"IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Saccharomyces cerevisiae": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IF-species-checked": "guaranteed", "IF-species-dilution-info": "", "IF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 1mL
Purity
IgG fraction
Storage buffer
pH: 7.2 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aldehyde Dehydrogenase (ALDH) an important enzyme responsible for oxidizing aldehydes into carboxylic acids participates in detoxifying aldehydes produced during various metabolic processes. ALDH has several isoforms including the well-studied ALDH2 which possesses a molecular mass of approximately 56 kDa. ALDH2 is found in many tissues but highest levels are in liver and kidney playing a significant role in processing endogenous aldehydes and those derived from external sources such as alcohol metabolism.
Biological function summary

Aldehyde Dehydrogenase influences the metabolism of aldehydrates aiding in the protection of cells from aldehyde-induced stress. ALDH exists within a larger family of enzymes and does not typically operate as part of a large complex. It helps maintain the balance of reactive aldehyde species in the cell through oxidation facilitating cellular protection against oxidative damage.

Pathways

Aldehyde Dehydrogenase plays an integral part in alcohol metabolism and the larger detoxification pathways. The enzyme ALDH2 is notably involved in the ethanol degradation pathway where it metabolizes acetaldehyde to acetate a less toxic compound. It interacts closely with alcohol dehydrogenase which initially forms acetaldehyde from ethanol establishing a sequential relationship within this critical metabolic pathway.

ALDH2's role is closely linked with alcoholism and Asian flush syndrome. ALDH2 deficiency impairs acetaldehyde detoxification leading to accumulation resulting in facial flushing and increased risk of alcoholism-related complications. Interaction with other proteins such as cytochrome P450 enzymes can impact the severity of these conditions as they are involved in overlapping detoxification pathways that handle a variety of substrates and drugs.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ALD2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39273244

2024

Strategies to Maintain Redox Homeostasis in Yeast Cells with Impaired Fermentation-Dependent NADPH Generation.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena Kwolek-Mirek,Roman Maslanka,Sabina Bednarska,Michał Przywara,Kornelia Kwolek,Renata Zadrag-Tecza

International journal of molecular sciences 24: PubMed36614102

2022

Unbalance between Pyridine Nucleotide Cofactors in The SOD1 Deficient Yeast Causes Hypersensitivity to Alcohols and Aldehydes.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena Kwolek-Mirek,Sabina Bednarska,Aleksandra Dubicka-Lisowska,Roman Maslanka,Renata Zadrag-Tecza,Pawel Kaszycki

Amino acids 44:235-44 PubMed21997537

2011

Retinoids produced by macrophages engulfing apoptotic cells contribute to the appearance of transglutaminase 2 in apoptotic thymocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Éva Garabuczi,Beáta Kiss,Szabolcs Felszeghy,Gregory J Tsay,László Fésüs,Zsuzsa Szondy
View all publications
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