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AB92519

Anti-Aldehyde Oxidase antibody

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(5 Publications)

Rabbit Polyclonal Aldehyde Oxidase antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human AOX1 aa 500-600.

View Alternative Names

AO, AOX1, Aldehyde oxidase, Aldehyde oxidase 1, Azaheterocycle hydroxylase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aldehyde Oxidase antibody (AB92519)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aldehyde Oxidase antibody (AB92519)

ab92519 at 1/50 dilution staining Aldehyde Oxidase in Human lung carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence (left) or presence (right) of the immunising peptide.

Western blot - Anti-Aldehyde Oxidase antibody (AB92519)
  • WB

Unknown

Western blot - Anti-Aldehyde Oxidase antibody (AB92519)

All lanes:

Western blot - Anti-Aldehyde Oxidase antibody (ab92519) at 1/500 dilution

Lane 1:

HeLa cell extracts at 30 µg

Lane 2:

HeLa cell extracts at 30 µg with immunising peptide

Predicted band size: 148 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human AOX1 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.

Q06278

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab92519 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aldehyde Oxidase (AOX) also known by alternate names such as aldehyde oxidoreductase is a cytosolic enzyme with a molecular mass of approximately 150 kDa. This enzyme expresses itself across various tissues including the liver lungs and other organs where it catalyzes the oxidation of aldehydes into acids. AOX requires molybdenum iron and flavin adenine dinucleotide (FAD) as cofactors enabling its activity in the detoxification of xenobiotic and endogenous aldehydes.
Biological function summary

Aldehyde oxidation involves processes that transform aldehydes into less reactive carboxylic acids aiding cellular regulatory functions. AOX plays a role within the molybdo-flavoenzyme complex. This complex participates in metabolic reactions that help maintain homeostasis within cells and manage oxidative stress. Its presence in the liver highlights its role in drug metabolism where it manages the oxidation of a variety of substances and reduces metabolic burden.

Pathways

One of the significant roles of aldehyde oxidase lies within the purine metabolism pathway. It helps convert purines into uric acid which supports the final steps of purine degradation. This enzyme shares pathways with xanthine oxidase another critical enzyme in purine catabolism. Additionally AOX participates in the biosynthesis and breakdown of several drugs and xenobiotics in the drug metabolism pathway exhibiting similarity to cytochrome P450 enzymes in its substrate preferences.

Aldehyde oxidase's dysfunction links to disorders like liver damage and certain neurological conditions due to its role in oxidative stress management. Impaired activity of AOX can lead to toxic aldehyde accumulation creating a harmful cellular environment that exacerbates liver damage. Furthermore AOX's connection with other enzymes such as xanthine oxidase relates it to conditions like gout where altered purine metabolism leads to excessive uric acid production and crystal formation in joints.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
See full target information AOX1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0329094 PubMed40986524

2025

Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuko Nakagawa,Takuro Horii,Ayako Fukunaka,Takashi Sato,Zhehao Zhang,Masaki Kobayashi,Tadahiro Kitamura,Yoshitaka Hayashi,Takashi Nishimura,Izuho Hatada,Yoshio Fujitani

Frontiers in oncology 13:1179212 PubMed37583929

2023

Identification and validation of immune-related hub genes based on machine learning in prostate cancer and AOX1 is an oxidative stress-related biomarker.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaocong Mo,Kaisheng Yuan,Di Hu,Cheng Huang,Juyu Luo,Hang Liu,Yin Li

Aging 15:2920-2936 PubMed37100467

2023

ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression.

Applications

Unspecified application

Species

Unspecified reactive species

Liqun Yang,Zhigang Dong,Shuyu Li,Tieliang Chen

Urologia internationalis 107:517-525 PubMed35354150

2022

DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jinfeng Wu,Yongbao Wei,Tao Li,Le Lin,Zesong Yang,Liefu Ye

Nutrients 14: PubMed35267991

2022

High-Fat Diet Augments the Effect of Alcohol on Skeletal Muscle Mitochondrial Dysfunction in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed Ismaeel,Joseph A Laudato,Emma Fletcher,Evlampia Papoutsi,Abigail Tice,Lara S Hwa,Dimitrios Miserlis,Athanasios Z Jamurtas,Jennifer Steiner,Panagiotis Koutakis
View all publications
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Product promise

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