Anti-ALDH16A1 antibody [EPR9217] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ALDH16A1 or aldehyde dehydrogenase 16 family member A1 belongs to the aldehyde dehydrogenase superfamily. This protein does not have well-documented enzymatic activity but it shares structural similarity with other family proteins suggesting a potential role in aldehyde metabolism. ALDH16A1 has a molecular mass of approximately 83 kDa. The protein expresses mainly in liver kidney and other tissues though its exact function remains unclear.

Biological function summary

Members of the aldehyde dehydrogenase family act in detoxification processes by oxidizing aldehydes into carboxylic acids reducing cellular damage. While ALDH16A1's activity remains undetermined its expression profile implies involvement in pathways where aldehyde metabolism impacts critical cellular functions. It does not form a known complex but its similarity with other aldehyde dehydrogenases suggests a supporting role in cellular detoxification pathways.

Pathways

Amino acid metabolism and detoxification pathways potentially involve ALDH16A1 due to its homology with other aldehyde dehydrogenases. This protein potentially interacts with enzymes such as ALDH2 which participates in ethanol metabolism and detoxification. Both proteins play roles in mitigating oxidative stress and processing toxic aldehydes ensuring cellular homeostasis.

Associated diseases and disorders

Polymorphisms or dysregulation in ALDH16A1 may correlate with metabolic disorders particularly those affecting kidney function. Further research implicates altered expression of this protein in conditions like diabetic nephropathy. The association with diabetes might tie into dysregulated aldehyde detoxification linking ALDH16A1 indirectly to proteins like ALDH2 known for roles in managing reactive aldehyde species and oxidative stress.