AB87117

Anti-ALDH1L1 antibody - Astrocyte Marker

Name: Anti-ALDH1L1 antibody - Astrocyte Marker (ab87117) | Abcam
Brand: Abcam Limited
SKU: AB87117
Price: 400 USD
Availability: InStock
Rating: 4 (11 reviews)

Lab Essentials
What is this?

(11 Reviews)

(94 Publications)

Anti-ALDH1L1 antibody - Astrocyte Marker (ab87117) is a rabbit polyclonal antibody detecting ALDH1L1 in Western Blot. Suitable for Mouse, Rat.

- Over 70 publications
- Trusted since 2010

View Alternative Names

Fthfd, Aldh1l1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1

1 Images

Unknown

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (AB87117)

All lanes:

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (ab87117) at 1 µg/mL

Lane 1:

Liver (Mouse) Tissue Lysate at 10 µg

Lane 2:

Brain (Mouse) Tissue Lysate at 10 µg

Lane 3:

Brain (Rat) Tissue Lysate at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 99 kDa

Observed band size: 100 kDa

true

Exposure time: 4min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

What is this antibody validated in?
Anti-ALDH1L1 antibody - Astrocyte Marker (ab87117) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB) in Mouse, Rat samples.

What is the molecular weight of ALDH1L1?
Anti-ALDH1L1 - Astrocyte Marker (ab87117) specifically detects a band for ALDH1L1 (UniProt: Q8R0Y6) at a molecular weight of 99kDa.

Trusted by the scientific community
Anti-ALDH1L1 - Astrocyte Marker (ab87117) was first used in a scientific publication in 2010 and has been cited over 70 times in peer-reviewed journals.

Reviewed by scientists
Anti-ALDH1L1 - Astrocyte Marker (ab87117) has over 5 independent reviews from customers.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALDH1L1 also known as 10-formyltetrahydrofolate dehydrogenase plays an important role as a metabolic enzyme involved in folate metabolism. Typically ALDH1L1 has a molecular mass of around 100 kDa. You can find this protein expressed strongly in the liver and brain particularly in astrocytes where it serves as a marker for these star-shaped glial cells. The expression of ALDH1L1 indicates its significant presence in these tissues helping researchers identify and study astrocyte function more effectively.

Biological function summary

ALDH1L1 is involved in the one-carbon metabolism pathway contributing to the conversion of formyl groups into CO2. This reaction aids in regulating cellular homeostasis and energy production. Within the biological context ALDH1L1 works independently and does not form a large complex but efficiently interacts with other enzymes involved in folate transformations. Its activity ensures proper folate cycle functioning supporting DNA synthesis and repair.

Pathways

ALDH1L1 importantly integrates into the folate metabolism pathway supporting detoxification and nucleotide biosynthesis. In this pathway ALDH1L1 interacts with the MTHFD1 protein to maintain the balance of one-carbon units necessary for nucleic acid synthesis. Furthermore ALDH1L1 interplays within the methionine cycle influencing the methylation processes important for gene expression and epigenetic regulation.

ALDH1L1 has associations with neurological conditions particularly Alzheimer's disease and glioblastoma. Changes in ALDH1L1 expression levels have implication in the progression of these diseases. In the context of glioblastoma researchers observe altered ALDH1L1 expression alongside traditional astrocyte markers like GFAP in the tumor microenvironment. Understanding ALDH1L1's role in these conditions could provide insights for developing therapeutic strategies targeting astrocyte behavior.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed : 31624291). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).

See full target information Aldh1l1

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Publications (94)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113335 PubMed40894864

2025

An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum.

Applications

Unspecified application

Species

Unspecified reactive species

Arpan Parichha,Debarpita Datta,Amrita Singh,Ishita Talwar,Shreya Yadav,Mahima Bose,Varun Suresh,Špela Miroševič,Nina Žakelj,David Gosar,Damjan Osredkar,Shubha Tole

Brain and neuroscience advances 9:23982128251351360 PubMed40718467

2025

Basal activation of astrocytic Nrf2 in neuronal culture media: Challenges and implications for neuron-astrocyte modelling.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed Moftah Omer Elsharkasi,Beatrice Villani,Geoffrey Wells,Fiona Kerr

Journal of neuroinflammation 22:183 PubMed40665351

2025

Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer's disease associated with inflammasome activation and ASC speck propagation.

Applications

Unspecified application

Species

Unspecified reactive species

Veronika Brezani,Radhika S Joshi,Marti Ortega-Ribera,Prashanth Thevkar Nagesh,Viliam Brezani,Adam Zivny,Evelyn A Kurt-Jones,Douglas T Golenbock,Gyongyi Szabo

Molecular neurodegeneration 20:73 PubMed40542358

2025

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Oliver J Ziff,Gustavo Morrone Parfitt,Sarah Jolly,Jackie M Casey,Lucy Granat,Satinder Samra,Núria Setó-Salvia,Argyro Alatza,Leela Phadke,Benjamin Galet,Philippe Ravassard,Marie-Claude Potier,John Hardy,Dervis A Salih,Paul Whiting,Fiona Ducotterd,Rickie Patani,Selina Wray,Charles Arber

eLife 13: PubMed40085500

2025

Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mahima Bose,Ishita Talwar,Varun Suresh,Urvi Mishra,Shiona Biswas,Anuradha Yadav,Shital T Suryavanshi,Simon Hippenmeyer,Shubha Tole

CNS neuroscience & therapeutics 31:e70231 PubMed39834103

2025

Electroacupuncture Pretreatment Reduces Ischemic Brain Injury by Inhibiting the Lactate Production and Its Derived Protein Lactylation Formation.

Applications

Unspecified application

Species

Unspecified reactive species

Xin-Ru Pan,Yao-Dan Zhang,Yuan-Hui Gan,Jia-Hang Zhang,Su-Jin Gao,Xiao-Shuang Feng,Jia-Xin Xie,Yu-Fei Wang,Xin-Xiao Zhang,Peng-Fei Wang,Shu-Guang Yu,Yong Tang,Xiao-Yi Xiong

The EMBO journal 44:382-412 PubMed39668249

2024

Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Wonyoung Lee,Byunghee Kang,Hyo-Min Kim,Tsuyoshi Ishida,Minkyung Shin,Misato Iwashita,Masahiro Nitta,Aki Shiraishi,Hiroshi Kiyonari,Koichiro Shimoya,Kazuto Masamoto,Tae-Young Roh,Yoichi Kosodo

Disease models & mechanisms 17: PubMed39526491

2024

Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Annesha C King,Emily Payne,Emily Stephens,Jahmel A Fowler,Tara E Wood,Efrain Rodriguez,Michelle Gray

The EMBO journal 43:5114-5140 PubMed39300210

2024

Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Yandong Zhang,Dan Li,Yuqun Cai,Rui Zou,Yilan Zhang,Xin Deng,Yafei Wang,Tianxiang Tang,Yuanyuan Ma,Feizhen Wu,Yunli Xie

Glia 72:2001-2021 PubMed39007459

2024

Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Charlotte Lorin,Romain Guiet,Nicolas Chiaruttini,Giovanna Ambrosini,Elvis Boci,Marwan Abdellah,Henry Markram,Daniel Keller

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ALDH1L1 antibody - Astrocyte Marker

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (AB87117)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (94)

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