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AB113496

Anti-ALDH1L2 antibody

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(4 Publications)

Rabbit Polyclonal ALDH1L2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Mitochondrial 10-formyltetrahydrofolate dehydrogenase aa 1-250.

View Alternative Names

Mitochondrial 10-formyltetrahydrofolate dehydrogenase, Mitochondrial 10-FTHFDH, mtFDH, Aldehyde dehydrogenase family 1 member L2, ALDH1L2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1L2 antibody (AB113496)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1L2 antibody (AB113496)

Staining of Human ALDH1L2 in a Formalin/PFA-fixed paraffin-embedded section of Human Fetal Heart using ab113496 at a dilution of 1/100.

Western blot - Anti-ALDH1L2 antibody (AB113496)
  • WB

Unknown

Western blot - Anti-ALDH1L2 antibody (AB113496)

All lanes:

Western blot - Anti-ALDH1L2 antibody (ab113496) at 1/1000 dilution

Lane 1:

Human Fetal Kidney Lysate

Lane 2:

Human Fetal Heart Lysate

Lane 3:

Human Fetal Liver Lysate

Predicted band size: 102 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Mitochondrial 10-formyltetrahydrofolate dehydrogenase aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q3SY69

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALDH1L2 also known as 10-formyltetrahydrofolate dehydrogenase 2 plays an important role in folate metabolism. It is a mitochondrial enzyme with an approximate mass of 100 kDa. This protein catalyzes the oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide impacting cellular methylation reactions. ALDH1L2 expresses mainly in the liver and kidney although its presence spans various tissues contributing to its diverse functionalities.
Biological function summary

ALDH1L2 facilitates important metabolic processes related to one-carbon metabolism a fundamental pathway in cell growth and replication. This protein functions as part of the formyltransferase complex collaborating with other enzymes to regulate folate and methionine cycles. This involvement in these cycles reflects its role in purine and nucleotide biosynthesis influencing genetic material synthesis and cellular repair mechanisms.

Pathways

The enzymatic activity of ALDH1L2 intersects the folate-mediated one-carbon metabolism and methionine cycle. This protein connects with the methionine synthase and methylenetetrahydrofolate reductase both vital in homocysteine metabolism. Its action ensures adequate supply of substrates required for DNA synthesis and repair suggesting its importance in maintaining genomic stability and nucleotide balance.

ALDH1L2 exhibits potential links to cancer and neurodegenerative conditions. Dysregulation of this enzyme could lead to folate imbalance influencing tumorigenesis by altering DNA methylation patterns. In neurodegenerative diseases variations in one-carbon metabolism levels have connections with Alzheimer's disease. Interaction with proteins like methionine synthase suggests that changes in this pathway could exacerbate neurological decline highlighting ALDH1L2 as a potential therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.
See full target information Mitochondrial 10-formyltetrahydrofolate dehydrogenase
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 11:3472-3488 PubMed33537098

2021

Overall survival of pancreatic ductal adenocarcinoma is doubled by deletion in the KPC mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Jae-Seon Lee,Ho Lee,Sang Myung Woo,Hyonchol Jang,Yoon Jeon,Hee Yeon Kim,Jaewhan Song,Woo Jin Lee,Eun Kyung Hong,Sang-Jae Park,Sung-Sik Han,Soo-Youl Kim

Scientific reports 9:16313 PubMed31705020

2019

Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.

Applications

Unspecified application

Species

Unspecified reactive species

Jae-Seon Lee,Seung Hwa Kim,Soohyun Lee,Joon Hee Kang,Seon-Hyeong Lee,Jae-Ho Cheong,Soo-Youl Kim

Cell 175:1546-1560.e17 PubMed30500537

2018

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxiang Zheng,Ting-Yu Lin,Gina Lee,Marcia N Paddock,Jessica Momb,Zhe Cheng,Qian Li,Dennis L Fei,Benjamin D Stein,Shivan Ramsamooj,Guoan Zhang,John Blenis,Lewis C Cantley

Acta biomaterialia 74:207-221 PubMed29777959

2018

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Majed Felemban,Birthe Dorgau,Nicola Claire Hunt,Dean Hallam,Darin Zerti,Roman Bauer,Yuchun Ding,Joseph Collin,David Steel,Natalio Krasnogor,Jumana Al-Aama,Susan Lindsay,Carla Mellough,Majlinda Lako
View all publications
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