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AB238866

Anti-ALDH3B2 antibody

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(2 Publications)

Rabbit Polyclonal ALDH3B2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ALDH3B2 aa 50-350.

View Alternative Names

ALDH8, ALDH3B2, Aldehyde dehydrogenase family 3 member B2, Aldehyde dehydrogenase 8, Long-chain fatty aldehyde dehydrogenase

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH3B2 antibody (AB238866)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH3B2 antibody (AB238866)

Paraffin-embedded human adrenal gland tissue stained for ALDH3B2 using ab238866 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ALDH3B2 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

P48448

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aldehyde dehydrogenase 3 family member B2 (ALDH3B2) is an enzyme that plays a significant role in the metabolism of aldehydes. This enzyme often referred to by its alternate name ALDH10 facilitates the oxidation of aldehydes into carboxylic acids an important detoxification process. ALDH3B2 has a molecular weight of approximately 55 kDa. Researchers have found its expression primarily in the liver and to a lesser extent in the kidney where it contributes to the breakdown of aldehyde substrates.
Biological function summary

ALDH3B2 contributes to the detoxification processes particularly in alcohol metabolism by removing toxic aldehydes from the body. It is not part of any larger multi-protein complex but functions independently to oxidize harmful aldehydes. This oxidation process assists in maintaining cellular health and preventing the accumulation of potentially damaging reactive molecules. Its activity ensures cellular protection against oxidative stress that can lead to liver damage and other pathological conditions.

Pathways

ALDH3B2 is involved in the alcohol dehydrogenase pathways and participates in ethanol metabolism. It closely interacts with alcohol dehydrogenase enzymes that facilitate the conversion of ethanol to acetaldehyde. ALDH3B2 then takes part in converting acetaldehyde to acetic acid supporting the continued breakdown of ethanol. This role places it in a critical metabolic route similar to but distinct from ALDH2 another member of the aldehyde dehydrogenase family highlighting its relevance in ethanol detoxification.

ALDH3B2 has implications in alcohol-related liver disease and certain forms of cancer. Changes or deficiencies in ALDH3B2 function can disrupt normal aldehyde detoxification enhancing susceptibility to liver damage associated with chronic alcohol consumption. Furthermore studies suggest links between ALDH3B2 activity and the development of certain cancers where it interacts with proteins involved in oxidative stress responses. These connections underline its role as a significant factor in hepatocellular carcinoma development through its interaction with oxidative stress pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Oxidizes medium and long chain fatty aldehydes in lipid droplets into non-toxic fatty acids.
See full target information ALDH3B2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of oncology 55:1003-1018 PubMed31545416

2019

Identification of new cancer stem cell markers and signaling pathways in HER‑2‑positive breast cancer by transcriptome sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Feng,Shangke Huang,Gaili An,Guanying Wang,Shanzhi Gu,Xinhan Zhao

Viruses 11: PubMed31018511

2019

Identification of RUVBL1 and RUVBL2 as Novel Cellular Interactors of the Ebola Virus Nucleoprotein.

Applications

Unspecified application

Species

Unspecified reactive species

M Jane Morwitzer,Sarah R Tritsch,Lisa H Cazares,Michael D Ward,Jonathan E Nuss,Sina Bavari,St Patrick Reid
View all publications
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Product promise

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