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AB228584

Anti-ALDH6A1 antibody

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(1 Publication)

Rabbit Polyclonal ALDH6A1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ALDH6A1.

View Alternative Names

MMSDH, ALDH6A1, Aldehyde dehydrogenase family 6 member A1, Malonate-semialdehyde dehydrogenase [acylating]

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH6A1 antibody (AB228584)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH6A1 antibody (AB228584)

Paraffin-embedded human liver carcinoma tissue stained for ALDH6A1 with ab228584 at 1/250 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH6A1 antibody (AB228584)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH6A1 antibody (AB228584)

Paraffin-embedded mouse stomach tissue stained for ALDH6A1 with ab228584 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-ALDH6A1 antibody (AB228584)
  • WB

Supplier Data

Western blot - Anti-ALDH6A1 antibody (AB228584)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-ALDH6A1 antibody (ab228584) at 1/500 dilution

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 30 µg

Predicted band size: 58 kDa

true

Western blot - Anti-ALDH6A1 antibody (AB228584)
  • WB

Supplier Data

Western blot - Anti-ALDH6A1 antibody (AB228584)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-ALDH6A1 antibody (ab228584) at 1/1000 dilution

All lanes:

Mouse liver tissue whole cell lysate at 50 µg

Predicted band size: 58 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ALDH6A1. The exact immunogen used to generate this antibody is proprietary information.

Q02252

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALDH6A1 also known as methylmalonate semialdehyde dehydrogenase (MMSDH) plays an important mechanical role in the metabolism of specific aldehydes. It belongs to the family of aldehyde dehydrogenases and has a molecular mass of approximately 58 kDa. ALDH6A1 is mainly expressed in human liver and kidney tissues. This protein catalyzes the conversion of methylmalonate semialdehyde to propionyl-CoA which is an essential step in the metabolism of branched-chain amino acids such as valine and isoleucine.
Biological function summary

ALDH6A1 contributes to cellular detoxification and energy production by participating in the breakdown of aldehydes which are toxic if accumulated. It is a part of the mitochondrial aldehyde dehydrogenase complex working alongside other enzymes for efficient catalysis. The enzyme's activity helps maintain cellular redox balance and supports energy metabolism directly impacting cellular function.

Pathways

ALDH6A1 plays a role within the propanoate metabolism and valine degradation processes. Through these pathways ALDH6A1 connects to proteins such as the branched-chain-amino-acid aminotransferase (BCAT) and propionyl-CoA carboxylase (PCC). These interactions facilitate the breakdown of amino acids into substrates that enter the citric acid cycle contributing to cellular energy generation.

Dysfunction of ALDH6A1 relates to metabolic disorders particularly methylmalonic aciduria. Patients with this condition accumulate methylmalonate semialdehyde and other toxic intermediates due to insufficient activity of the enzyme. Additionally interactions between ALDH6A1 and proteins like PCC can compound metabolic issues since both are involved in propionate metabolism linking their dysfunctions to similar metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
See full target information ALDH6A1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncogene 41:782-796 PubMed34853466

2021

GTF2E2 is a novel biomarker for recurrence after surgery and promotes progression of esophageal squamous cell carcinoma via miR-139-5p/GTF2E2/FUS axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Zhang,Yuxin Zhang,Bo Ai,Juejun Gong,Yichen Li,Shiying Yu,Xiuyu Cai,Li Zhang
View all publications
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Product promise

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