JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB49947

Anti-Aldosterone 3 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Aldosterone 3 antibody. Suitable for RIA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Aldosterone 3.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

RIA

applications

Specificity

Cross Reactivity: 11- Deoxycorticosterone 1.1% Estradiol < 0.001% 11- Deoxycortisol < 0.001% Androsterone < 0.001% 21- Deoxycortisol < 0.001% Estriol < 0.001% Cortisone < 0.001% Estrone < 0.001% Testosterone < 0.01% Dihydrotesterone < 0.001%

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aldosterone 3 known also as CYP11B2 is an enzyme involved in the biosynthesis of aldosterone. It belongs to the cytochrome P450 family and exhibits a mass of approximately 58 kDa. The enzyme is highly expressed in the zona glomerulosa of the adrenal cortex where it facilitates the conversion of corticosterone to aldosterone by catalytic hydroxylation processes. The key role of Aldosterone 3 in this conversion highlights its important enzymatic function in steroid hormone production.
Biological function summary

The process of converting corticosterone into aldosterone by CYP11B2 contributes significantly to the regulation of blood pressure and fluid balance. This enzyme operates within a complex of electron transfer proteins ensuring the supply of electrons for effective catalysis. It partners with adrenodoxin and adrenodoxin reductase to perform its functions. This cooperation allows for the precise control of aldosterone release into the bloodstream affecting the balance of sodium and potassium.

Pathways

Aldosterone 3 plays an important role in the renin-angiotensin-aldosterone system (RAAS) which is central to cardiovascular regulation and fluid homeostasis. Within this pathway CYP11B2 activity links closely with angiotensin II a peptide that stimulates its expression and action. RAAS integrates the function of other proteins such as aldosterone synthase connecting several feedback mechanisms that control blood pressure.

Mutations or dysregulation in CYP11B2 are linked to conditions like primary aldosteronism and hypertension. Alterations in Aldosterone 3 activity lead to imbalances in aldosterone secretion which can cause high blood pressure or contribute to cardiovascular diseases. The enzyme’s relationship with angiotensin-converting enzyme (ACE) through RAAS adds complexity to how it impacts disease processes bridging connections between genetic molecular and systemic levels in the development of these health conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information Aldosterone 3
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 281:1750-8 PubMed24495014

2014

Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Fan,Bing Shen,Mingyue Tan,Xinyu Mu,Yan Qin,Fang Zhang,Yong Liu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB241065

Anti-Aldosterone antibody [EPPTX-R9-134-1]

RabMAb|Recombinant

Competitive ELISA - Anti-Aldosterone antibody [EPPTX-R9-134-1] (AB241065)

  • 0
  • 0
Primary Antibodies

AB251586

Anti-Aldosterone antibody [EPPTX-R9-134-1] - BSA and Azide free

RabMAb|Recombinant

Competitive ELISA - Anti-Aldosterone antibody [EPPTX-R9-134-1] - BSA and Azide free (AB251586)

  • 0
  • 0
Primary Antibodies

AB116600

Anti-Cortisol antibody [F4P1A3]

  • 0
  • 0
Assay Kits

AB136933

Aldosterone ELISA kit

Competitive ELISA - Aldosterone ELISA kit (AB136933)

  • 5
  • 2

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com