Rabbit Polyclonal Aldosterone 3 antibody. Suitable for RIA and reacts with Chemical samples. Immunogen corresponding to Chemical / Small Molecule corresponding to Aldosterone 3.
Constituents: Whole serum
| RIA | |
|---|---|
| Chemical | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Chemical | Dilution info Use at an assay dependent concentration. | Notes - |
Rabbit Polyclonal Aldosterone 3 antibody. Suitable for RIA and reacts with Chemical samples. Immunogen corresponding to Chemical / Small Molecule corresponding to Aldosterone 3.
Constituents: Whole serum
Cross Reactivity: 11- Deoxycorticosterone 1.1% Estradiol < 0.001% 11- Deoxycortisol < 0.001% Androsterone < 0.001% 21- Deoxycortisol < 0.001% Estriol < 0.001% Cortisone < 0.001% Estrone < 0.001% Testosterone < 0.01% Dihydrotesterone < 0.001%
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Aldosterone 3 known also as CYP11B2 is an enzyme involved in the biosynthesis of aldosterone. It belongs to the cytochrome P450 family and exhibits a mass of approximately 58 kDa. The enzyme is highly expressed in the zona glomerulosa of the adrenal cortex where it facilitates the conversion of corticosterone to aldosterone by catalytic hydroxylation processes. The key role of Aldosterone 3 in this conversion highlights its important enzymatic function in steroid hormone production.
The process of converting corticosterone into aldosterone by CYP11B2 contributes significantly to the regulation of blood pressure and fluid balance. This enzyme operates within a complex of electron transfer proteins ensuring the supply of electrons for effective catalysis. It partners with adrenodoxin and adrenodoxin reductase to perform its functions. This cooperation allows for the precise control of aldosterone release into the bloodstream affecting the balance of sodium and potassium.
Aldosterone 3 plays an important role in the renin-angiotensin-aldosterone system (RAAS) which is central to cardiovascular regulation and fluid homeostasis. Within this pathway CYP11B2 activity links closely with angiotensin II a peptide that stimulates its expression and action. RAAS integrates the function of other proteins such as aldosterone synthase connecting several feedback mechanisms that control blood pressure.
Mutations or dysregulation in CYP11B2 are linked to conditions like primary aldosteronism and hypertension. Alterations in Aldosterone 3 activity lead to imbalances in aldosterone secretion which can cause high blood pressure or contribute to cardiovascular diseases. The enzyme’s relationship with angiotensin-converting enzyme (ACE) through RAAS adds complexity to how it impacts disease processes bridging connections between genetic molecular and systemic levels in the development of these health conditions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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