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AB217927

Anti-ALEX1 antibody

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(2 Publications)

Rabbit Polyclonal ALEX1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ARMCX1 aa 250-350 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

ALEX1, AD032, ARMCX1, Armadillo repeat-containing X-linked protein 1, ARM protein lost in epithelial cancers on chromosome X 1, Protein ALEX1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALEX1 antibody (AB217927)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALEX1 antibody (AB217927)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse ovary tissue labeling ALEX1 with ab217927 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ARMCX1 aa 250-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9P291

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ALEX1 protein also known as 'Armadillo Repeat Containing X-Linked 1' plays a role in cellular mechanisms. The protein has a molecular mass of approximately 90 kDa. Researchers found ALEX1 expression mainly in the brain and testis suggesting it might have tissue-specific roles. Its alternate name 'ARMCX1' reflects its structural features notably the presence of armadillo repeats which are important for protein-protein interactions.
Biological function summary

ALEX1 contributes to cellular growth and development. It forms part of a larger protein complex engaging in interactions that regulate cytoskeletal dynamics and signal transduction. The roles of ALEX1 in neurons suggest it might influence neuronal connectivity and maintenance. This makes researchers interested in understanding its detailed biological functions in the nervous system and reproductive tissues.

Pathways

Researchers place ALEX1 in signal transduction pathways relevant to cellular communication and maintenance. One important association is the Wnt signaling pathway a pathway known to govern cell growth and differentiation. ALEX1's interaction with other armadillo family proteins like beta-catenin has been observed in these pathways. This connection suggests a regulatory role that influences multiple downstream effects within cells.

ALEX1 appears in studies related to neurodegenerative diseases and cancers. Its altered expression profiles have implications in conditions such as Alzheimer's disease as well as testicular cancer. In Alzheimer's researchers have noted interactions with Tau protein a factor known for its involvement in neurofibrillary tangles. In cancers ALEX1's interaction with beta-catenin is of particular interest as it lends understanding to the dynamics of cellular proliferation and apoptosis in tumorigenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.
See full target information ARMCX1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed40028769

2025

The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chengfang Pan,Ying Liu,Liangya Wang,Wen-Yong Fan,Yunzhi Ni,Xuefeng Zhang,Di Wu,Chenyang Li,Jin Li,Zhaoyang Li,Rui Liu,Changlong Hu

Genesis (New York, N.Y. : 2000) 62:e23615 PubMed39139090

2024

Generation of an Armcx1 Conditional Knockout Mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Cora L Bright,Howard M Bomze,Mantu Bhaumik,Jeremy N Kay,Romain Cartoni,Sidney M Gospe
View all publications
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