Rabbit Recombinant Monoclonal CGBP antibody - conjugated to Alexa Fluor® 488.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
CFP1, CGBP, PCCX1, PHF18, CXXC1, CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1
Rabbit Recombinant Monoclonal CGBP antibody - conjugated to Alexa Fluor® 488.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
CGBP also known as CpG-binding protein is a DNA-binding protein with a mass of about 66 kDa. It is recognized for its function in binding to unmethylated CpG motifs in DNA. Scientists have observed its expression mainly in the nucleus where it plays a significant role in regulating gene expression. The interaction with these CpG regions is essential for maintaining gene activity and stability.
CGBP influences the transcriptional regulation by acting as a transcription factor. This protein is part of a complex that includes other regulatory proteins assisting in the activation of specific gene sets. It participates by directing the cellular signals that modulate chromatin structure impacting the transcriptional landscape of several genes.
CGBP interacts with cellular mechanisms that involve DNA methylation and histone modification. It is integrated within pathways like the Wnt signaling pathway and is related to proteins such as DNMT1 which is important for DNA methylation processes. This interaction supports its role in modulating gene silencing and activation across different cellular contexts.
Scientists have linked CGBP to cancer and autoimmune diseases. Alterations in CGBP expression or function can disrupt normal epigenetic regulation contributing to oncogenesis and immune dysregulation. In cancer its interaction with DNMT1 further associates it with aberrant methylation patterns a hallmark of many tumors. Similarly dysregulation of CGBP can influence pathways leading to autoimmune conditions complicating immune cell homeostasis.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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