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AB318556

Alexa Fluor® 488 Anti-CGBP antibody [EPR19199] - ChIP Grade

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Rabbit Recombinant Monoclonal CGBP antibody - conjugated to Alexa Fluor® 488.

View Alternative Names

CFP1, CGBP, PCCX1, PHF18, CXXC1, CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1

  • Unconjugated

    Anti-CGBP antibody [EPR19199] - ChIP Grade

  • Carrier free

    Anti-CGBP antibody [EPR19199] - BSA and Azide free

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-CGBP antibody [EPR19199] - ChIP Grade

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-CGBP antibody [EPR19199] - ChIP Grade

  • 660 APC

    APC Anti-CGBP antibody [EPR19199] - ChIP Grade

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-CGBP antibody [EPR19199] - ChIP Grade

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-CGBP antibody [EPR19199] - ChIP Grade

  • 578 PE

    PE Anti-CGBP antibody [EPR19199] - ChIP Grade

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR19199

Isotype

IgG

Conjugation

Alexa Fluor® 488

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CGBP also known as CpG-binding protein is a DNA-binding protein with a mass of about 66 kDa. It is recognized for its function in binding to unmethylated CpG motifs in DNA. Scientists have observed its expression mainly in the nucleus where it plays a significant role in regulating gene expression. The interaction with these CpG regions is essential for maintaining gene activity and stability.
Biological function summary

CGBP influences the transcriptional regulation by acting as a transcription factor. This protein is part of a complex that includes other regulatory proteins assisting in the activation of specific gene sets. It participates by directing the cellular signals that modulate chromatin structure impacting the transcriptional landscape of several genes.

Pathways

CGBP interacts with cellular mechanisms that involve DNA methylation and histone modification. It is integrated within pathways like the Wnt signaling pathway and is related to proteins such as DNMT1 which is important for DNA methylation processes. This interaction supports its role in modulating gene silencing and activation across different cellular contexts.

Scientists have linked CGBP to cancer and autoimmune diseases. Alterations in CGBP expression or function can disrupt normal epigenetic regulation contributing to oncogenesis and immune dysregulation. In cancer its interaction with DNMT1 further associates it with aberrant methylation patterns a hallmark of many tumors. Similarly dysregulation of CGBP can influence pathways leading to autoimmune conditions complicating immune cell homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
See full target information CXXC1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com