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AB309868

Alexa Fluor® 488 Anti-PWP1 antibody [EPR16130]

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Rabbit Recombinant Monoclonal PWP1 antibody - conjugated to Alexa Fluor® 488.

View Alternative Names

Periodic tryptophan protein 1 homolog, Keratinocyte protein IEF SSP 9502, PWP1

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR16130

Isotype

IgG

Conjugation

Alexa Fluor® 488

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PWP1 protein also known as Periodic tryptophan protein 1 homolog is a 90 kDa nuclear protein that participates in the assembly of ribosomal subunits. It is predominantly expressed in the nucleolus and is part of the WD40 protein family characterized by repeating units that form a β-propeller structure. This structure facilitates its interaction with various molecular partners allowing it to play a role in ribosome biogenesis.
Biological function summary

PWP1 is involved in the nucleolar function and ribosome production. It acts as part of a multiprotein complex that assists in the maturation of pre-ribosomal particles. The protein contributes to the processing and assembly of ribosomal RNA ensuring proper ribonucleoprotein configuration. This function is especially important in regulating gene expression by controlling protein synthesis at the ribosomal level.

Pathways

PWP1 is a component of the ribosome biogenesis pathway which integrates its activity with other proteins such as NOP58 and RRP9. It is also linked to the RNA processing pathway where it interacts with other nucleolar proteins to ensure accurate RNA transcription and modification. These pathways are essential for maintaining cellular homeostasis and responding to growth signals impacting cell proliferation.

PWP1's dysfunction has connections with cancer and disorders relating to ribosomal dysregulation. Aberrant expression or mutation of PWP1 may lead to disruptions in ribosomal biogenesis contributing to oncogenesis. The protein is associated with abnormal regulatory networks alongside proteins like NPM1 which also plays a role in tumorigenesis. Investigations into PWP1 offer insights into potential biomarkers and targets for therapeutic intervention in ribosome-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chromatin-associated factor that regulates transcription (PubMed : 29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed : 29065309). Regulates the epigenetic status of rDNA (PubMed : 29065309).
See full target information PWP1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Version
Primary Antibodies

AB251037

Anti-PWP1 antibody [EPR16130] - BSA and Azide free

primary-antibodies

pwp1-antibody-epr16130-bsa-and-azide-free-ab251037

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