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AB309730

Alexa Fluor® 488 Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

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Rabbit Recombinant Monoclonal Stanniocalcin 2/STC-2 antibody - conjugated to Alexa Fluor® 488.

View Alternative Names

Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2

  • 578 PE

    PE Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • 660 APC

    APC Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • HRP

    HRP Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR22866-10

Isotype

IgG

Conjugation

Alexa Fluor® 488

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Applications

Target Binding Affinity, Antibody Labelling

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Stanniocalcin 2 (STC-2) is a glycoprotein hormone known for regulating calcium and phosphate homeostasis. It has other names like STC-1-related protein and STC2. The protein has a mass of approximately 33 kDa. STC-2 expresses in various tissues with high levels in the liver kidney and thyroid gland. Its expression suggests an important role in maintaining mineral balance in these tissues.
Biological function summary

STC-2 influences metabolic and inflammatory processes by modulating cellular responses to calcium and phosphate. It operates partly by binding to receptors on cell surfaces impacting cell proliferation and survival. While not part of a known complex STC-2 interacts with signaling molecules involved in bone metabolism and endocrine function serving as a modulator of mineralized tissue homeostasis.

Pathways

In mineral homeostasis STC-2 interacts within pathways involving calcium and phosphate regulation. Its interactions include overlap with the PTH (parathyroid hormone) and vitamin D pathways each critical for calcium and bone metabolism. STC-2 shows connections with proteins like FGF23 (fibroblast growth factor 23) that also participate in these regulatory networks impacting how cells manage mineral concentrations.

Research indicates STC-2's involvement in conditions such as chronic kidney disease and some cancers. Its expression levels correlate with abnormal mineral metabolism in kidney disease where it may interact with proteins like Klotho a known regulator of phosphate transport. In oncology overexpression of STC-2 associates with cancer progression potentially linking to altered signaling pathways in tumor cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
See full target information Stanniocalcin-2
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Complementary Products

Assay Kits

AB320044

Human Stanniocalcin 2 / STC-2 ELISA Kit- Extracellular

Recombinant|SimpleStep

Sandwich ELISA - Human Stanniocalcin 2 / STC-2 ELISA Kit- Extracellular (AB320044)

  • 0
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Assay Kits

AB320055

Human Stanniocalcin 2 / STC-2 ELISA Kit- Intracellular

Recombinant|SimpleStep

Sandwich ELISA - Human Stanniocalcin 2 / STC-2 ELISA Kit- Intracellular (AB320055)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com