Rabbit Recombinant Monoclonal VMAT1 antibody - conjugated to Alexa Fluor® 488.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Isoform 1. Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:16326835, PubMed:23337945, PubMed:8643547). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (PubMed:23337945). Isoform 2. Unable to uptake serotonin.
VAT1, VMAT1, SLC18A1, Chromaffin granule amine transporter, Solute carrier family 18 member 1, Vesicular amine transporter 1
Rabbit Recombinant Monoclonal VMAT1 antibody - conjugated to Alexa Fluor® 488.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
Vesicular monoamine transporter 1 (VMAT1) also known as solute carrier family 18 member 1 (SLC18A1) facilitates the transport of monoamines—such as dopamine serotonin and norepinephrine—into synaptic vesicles. VMAT1 with a molecular weight of approximately 46 kDa is particularly expressed in neuroendocrine cells. These are present in tissues like the adrenal medulla and various parts of the central nervous system. Its transporter function is critical for monoamine storage and release essentially influencing neurotransmitter recycling.
VMAT1 is involved in the modulation of neural signaling processes. It functions as a monoamine transporter by regulating neurotransmitter levels within vesicles preparing them for secretion. By doing so it influences synaptic transmission and signal transduction impacting mood cognition and other neural activities. VMAT1 operates as part of a vesicular transport machinery functioning alongside other proteins that maintain neurotransmitter balance.
VMAT1 plays an important role in the catecholamine and serotonin neurotransmitter pathways. It associates with proteins like dopamine transporter (DAT) and serotonin transporter (SERT) to maintain neurotransmitter homeostasis. These pathways are integral for mood regulation and stress responses. Interactions within these pathways are vital for maintaining synaptic stability and efficient neurotransmitter exchange.
VMAT1 has been implicated in neuropsychiatric conditions such as schizophrenia and mood disorders. Altered VMAT1 function may disrupt monoamine storage and release contributing to imbalances observed in these disorders. The interaction with related proteins such as DAT highlights its role in dopamine-related dysfunction in these diseases. Understanding VMAT1's involvement in these conditions aids the development of targeted therapies to correct neurotransmitter imbalances.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com