Rabbit Recombinant Monoclonal TAU antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
MAPT, TAU_HUMAN
MAPTL, MTBT1, TAU, MAPT, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
Rabbit Recombinant Monoclonal TAU antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
4R Tau also known as the 4-repeat tau protein plays a significant role in the stabilization of microtubules in neurons. This protein appears mainly in the human central nervous system where it assists in axonal structure and transport. 4R Tau has a molecular weight of approximately 65 kDa. The expression of 4R Tau occurs mostly in neurons although its presence can also be detected in other cell types within the brain.
4R Tau is a component essential for the assembly and maintenance of neuronal microtubules. It regulates microtubule dynamics by binding and enhancing their stability important for maintaining cellular and axonal integrity. In mature neurons 4R Tau exists as part of a complex with tubulin forming an important element for axonal morphology. Its function extends further into modulating neuronal growth and signal transmission which directly impacts neural connectivity.
4R Tau is integral within the microtubule-associated protein tau (MAPT) signaling pathways. It interacts with other proteins that influence microtubule assembly and stability such as tubulin and MAP2 playing a significant role in cytoskeletal development. Additionally 4R Tau is involved in the protein folding pathways regulated by chaperones like Heat Shock Protein 70 (Hsp70) which affect its aggregation and function within neural cells.
4R Tau is closely associated with neurodegenerative conditions such as Alzheimer's disease and frontotemporal dementia. Aberrant phosphorylation and aggregation of 4R Tau drive pathological tau tangles which disrupt neural networks and lead to cognitive decline. In Alzheimer’s the protein's dysfunction is linked with amyloid-beta peptide which accelerates tau pathology progression. Similarly in frontotemporal dementia 4R Tau's abnormal activity is influenced by interactions with proteins such as TDP-43 highlighting its central role in these neurodegenerative disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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