Rabbit Recombinant Monoclonal ACTL8 antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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Actin-like protein 8, Cancer/testis antigen 57, CT57, ACTL8
Rabbit Recombinant Monoclonal ACTL8 antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
ACTL8 also known as Actin-Like 8 is a protein with a mass around 45 kDa. This protein is a member of the actin-related proteins that share structural similarities with conventional actin. ACTL8 is mainly expressed in the testis and to a lesser extent in the brain and other tissues. It plays a role in cellular processes that involve cytoskeletal dynamics.
Actin-Like 8 participates in intracellular transport and cell shape changes. It doesn't appear to form part of a well-defined complex but it may interact with other actin-related proteins and myosins in the testis. Its function is important in the development and maintenance of sperm tail structure suggesting a role in spermatogenesis.
ACTL8 is involved in actin cytoskeleton remodeling pathways. It connects to the Wnt signaling pathway which influences cell proliferation and differentiation. ACTL8 may interact with proteins like beta-catenin that bridge Wnt signaling and cytoskeletal organization which is important for cellular adhesion and migration processes.
Disturbances in ACTL8 expression have correlations with reproductive disorders such as non-obstructive azoospermia where sperm cells are not produced. It also has connections to neurological conditions given its expression in the brain although this is less well understood. Its interaction with proteins involved in cytoskeletal regulation such as other actins might influence disease states where cell movement and structure are affected.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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