JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB312247

Alexa Fluor® 555 Anti-C1QC antibody [EPR2984Y]

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Recombinant Monoclonal C1QC antibody - conjugated to Alexa Fluor® 555.

View Alternative Names

C1QG, C1QC, Complement C1q subcomponent subunit C

  • 578 PE

    PE Anti-C1QC antibody [EPR2984Y]

  • 660 APC

    APC Anti-C1QC antibody [EPR2984Y]

  • HRP

    HRP Anti-C1QC antibody [EPR2984Y]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-C1QC antibody [EPR2984Y]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-C1QC antibody [EPR2984Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-C1QC antibody [EPR2984Y]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-C1QC antibody [EPR2984Y]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-C1QC antibody [EPR2984Y]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR2984Y

Isotype

IgG

Conjugation

Alexa Fluor® 555

Excitation/Emission

Ex: 555nm, Em: 565nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C1QC also known as complement component C1q subcomponent subunit C serves a mechanical role in the immune system. The C1QC protein with a molecular mass of about 26 kDa is primarily expressed in immune cells such as macrophages and dendritic cells. C1QC is part of the C1 complex which consists of C1q C1r and C1s subcomponents. This complex initiates the classical complement pathway by recognizing and binding to pathogens or apoptotic cells leading to their clearance from the body.
Biological function summary

C1QC is important for recognizing pathogens and apoptotic cells. C1QC is a part of the larger C1 complex essential for immune response effectiveness. By binding to surface molecules on pathogens C1QC triggers a cascade of events that promote cell lysis or phagocytosis. This protein by facilitating immune complex clearance also helps maintain tissue homeostasis and contributes to protection against infections.

Pathways

C1QC plays important roles in the classical complement pathway. Once C1QC identifies a target it activates C1r and C1s initiating a series of proteolytic interactions that result in the formation of the membrane attack complex. Additionally C1QC interacts with proteins like mannose-binding lectin in related pathways linking innate immunity components and further enhancing the body's defense mechanisms.

C1QC has connections to systemic lupus erythematosus (SLE) and Alzheimer's disease. Deficiencies or dysregulation of C1QC could lead to autoimmune conditions like SLE where the body attacks its own tissues due to inadequate clearance of apoptotic cells. In Alzheimer's disease impaired C1QC function may affect amyloid-beta clearance which is important for preventing neuronal damage. When discussing C1QC’s connections with other proteins the interaction with C1QA and C1QB within the C1 complex is significant in these disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
See full target information C1QC
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB71940

Anti-C1q antibody [JL-1]

Dot Blot - Anti-C1q antibody [JL-1] (AB71940)

  • 4
  • 12
Proteins & Peptides

AB91203

Mouse C1QA peptide

  • 0
  • 0
Primary Antibodies

AB200999

Anti-C3 antibody [EPR19394]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-C3 antibody [EPR19394] (AB200999)

  • 4
  • 9
Proteins & Peptides

AB157984

Recombinant Human C1QC protein

SDS-PAGE - Recombinant Human C1QC protein (AB157984)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com