Rabbit Recombinant Monoclonal MED7 antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
ARC34, CRSP9, MED7, Mediator of RNA polymerase II transcription subunit 7, hMED7, Activator-recruited cofactor 34 kDa component, Cofactor required for Sp1 transcriptional activation subunit 9, Mediator complex subunit 7, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33, CRSP complex subunit 9
Rabbit Recombinant Monoclonal MED7 antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
MED7 also known as Mediator Complex Subunit 7 is a protein component of core Mediator complex essential for transcription regulation by RNA polymerase II. MED7 weighs approximately 25 kDa and exists in nucleus. It is part of a large multi-protein assembly. This subunit participates specifically by aiding in the mediator's interactions with gene-specific regulatory proteins and general transcription factors essential for transcription initiation.
These components coordinate as part of Mediator complex which regulates transcription by acting as bridge between DNA-bound transcriptional regulators and RNA polymerase II. MED7 contributes to the structural integrity of Mediator complex affecting transcriptional activation processes necessary for gene expression. The protein's roles link it directly to cell growth differentiation and response to various stimuli indicating its importance in diverse cellular processes.
MED7 integrates itself into transcription regulation pathways especially interacting with other subunits like MED1 and MED14. The Mediator complex functions in the pathway responsible for transferring information from transcription factors to RNA polymerase II. This involves interacting with multiple pathways including Notch signaling and Wnt signaling serving as coordinator between transcriptional regulators and transcription machinery.
MED7 has associations with cancer and neurodevelopmental disorders. Aberrations in Mediator complex components including MED7 can impact transcriptional dysregulation linked to oncogenesis. Mutations in this subunit along with changes in associated proteins such as MED12 are observed in various cancer types. Additionally disturbances in Mediator complex function potentially involving MED7 contribute to neurodevelopmental conditions due to misregulation of gene expression essential for neural development.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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