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AB312058

Alexa Fluor® 555 Anti-PSMD9 antibody [EPR12947]

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Rabbit Recombinant Monoclonal PSMD9 antibody - conjugated to Alexa Fluor® 555.

View Alternative Names

26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, PSMD9

  • 578 PE

    PE Anti-PSMD9 antibody [EPR12947]

  • 660 APC

    APC Anti-PSMD9 antibody [EPR12947]

  • HRP

    HRP Anti-PSMD9 antibody [EPR12947]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-PSMD9 antibody [EPR12947]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-PSMD9 antibody [EPR12947]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-PSMD9 antibody [EPR12947]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-PSMD9 antibody [EPR12947]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-PSMD9 antibody [EPR12947]

  • Unconjugated

    Anti-PSMD9 antibody [EPR12947]

  • Carrier free

    Anti-PSMD9 antibody [EPR12947] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12947

Isotype

IgG

Conjugation

Alexa Fluor® 555

Excitation/Emission

Ex: 555nm, Em: 565nm

Carrier free

No

Applications

Target Binding Affinity, Antibody Labelling

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PSMD9 also known as 26S proteasome non-ATPase regulatory subunit 9 or Bridge-1 is a component of the 26S proteasome complex. This protein has a mass of approximately 49 kDa. It plays a role in regulating the degradation of ubiquitinated proteins through its function in the proteasome complex. The protein is expressed in multiple tissues including skeletal muscle and heart.
Biological function summary

PSMD9 participates in proteasomal degradation of intracellular proteins facilitating protein turnover and maintaining cellular homeostasis. It integrates into the 26S proteasome complex consisting of the 20S core particle and the 19S regulatory particle. Within the proteasome PSMD9 interacts with various subunits to regulate the recognition and unfolding of ubiquitinated substrates.

Pathways

PSMD9 plays an important role in the ubiquitin-proteasome pathway which is essential for protein regulation and quality control in cells. This pathway involves tagging proteins with ubiquitin for degradation. PSMD9 shows functional relationships with other proteasome subunits like PSMD4 and PSMD11 which participate in similar regulation processes.

Dysfunction of the ubiquitin-proteasome pathway involving PSMD9 contributes to neurodegenerative diseases such as Alzheimer's disease and certain types of cancer. In Alzheimer's improper proteasomal activity can lead to the accumulation of damaged proteins. PSMD9's activity links it to other proteins implicated in these diseases including PSMD1 and the amyloid precursor protein in Alzheimer's disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9 : PSMC6 : PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
See full target information 26S proteasome non-ATPase regulatory subunit 9
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Complementary Products

Assay Kits

AB284019

Human PSMD9 ELISA Kit

Sandwich ELISA - Human PSMD9 ELISA Kit (AB284019)

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Proteins & Peptides

AB137154

Recombinant Human PSMD9 protein

SDS-PAGE - Recombinant Human PSMD9 protein (AB137154)

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Assay Kits

AB284019

Human PSMD9 ELISA Kit

Sandwich ELISA - Human PSMD9 ELISA Kit (AB284019)

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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