Rabbit Recombinant Monoclonal SNRPD2 antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077).
SNRPD1, SNRPD2, Small nuclear ribonucleoprotein Sm D2, Sm-D2, snRNP core protein D2
Rabbit Recombinant Monoclonal SNRPD2 antibody - conjugated to Alexa Fluor® 555.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
The small nuclear ribonucleoprotein D2 (SNRPD2) also known as Sm-D2 is a component of the spliceosomal small nuclear ribonucleoproteins (snRNP) essential for pre-mRNA splicing. It has a molecular weight of approximately 14 kDa and is ubiquitously expressed in various tissues highlighting its significant function across different cell types. SNRPD2 is part of the Sm protein family which plays an important role in the assembly and function of spliceosomal snRNPs.
SNRPD2 participates in the formation of the spliceosomal core necessary for the removal of introns from pre-mRNA which is important for generating mature mRNA transcripts. This protein is a part of the spliceosome complex consisting of other snRNPs and numerous accessory proteins. SNRPD2's involvement in mRNA processing highlights its fundamental role in gene expression regulation affecting how cells translate genetic information into functional proteins.
SNRPD2 is a critical element in the spliceosome pathway a major route for the post-transcriptional modification of RNA. This pathway is integral to the regulation of alternative splicing events influencing protein diversity. SNRPD2 also interacts with other spliceosomal proteins such as SNRPB and SNRPE cooperating to facilitate precise exon-exon junctions. The fidelity of this pathway depends substantially on the integrity and functionality of SNRPD2 alongside its protein partners.
SNRPD2 shows a connection to autoimmune conditions such as systemic lupus erythematosus (SLE) where autoantibodies target snRNP components including SNRPD2. This autoimmune disorder may disrupt normal spliceosomal function contributing to disease pathology. Additionally alterations in splicing pathways involving SNRPD2 have links to certain cancers where dysregulated splicing can lead to oncogenic transformations. Understanding SNRPD2's role in these conditions may reveal therapeutic targets for modulating splicing in disease contexts.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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