Rabbit Recombinant Monoclonal HDAC2 antibody - conjugated to Alexa Fluor® 568.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827).
Histone deacetylase 2, HD2, Protein deacylase HDAC2, HDAC2
Rabbit Recombinant Monoclonal HDAC2 antibody - conjugated to Alexa Fluor® 568.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
HDAC1 and HDAC2 also known as histone deacetylase 1 and 2 are enzymes that remove acetyl groups from histone proteins leading to chromatin condensation and transcriptional repression. HDAC1 has a molecular weight of approximately 62 kDa and is expressed in various cell types including those in the central nervous system heart and immune cells. HDAC2 shares similar expression patterns with a molecular weight around 55 kDa. Both proteins play a role in regulating gene expression by altering chromatin structure.
Both HDAC1 and HDAC2 are components of large multiprotein complexes such as the Sin3 NuRD and CoREST complexes which are involved in transcriptional regulation. These complexes facilitate the deacetylation of histones transcription factors and other cellular proteins influencing cell cycle progression differentiation and development. HDAC1 and HDAC2 modulate cellular activities impacting cell proliferation and survival.
HDAC1 and HDAC2 participate in key cellular processes particularly the cell cycle and apoptosis pathways. These enzymes closely interact with proteins like pRb and E2F influencing the transition between different cell cycle phases. HDAC1 and HDAC2 also connect with tumor suppressor protein p53 affecting apoptotic pathways. By modulating these pathways they play an essential role in maintaining cellular homeostasis.
HDAC1 and HDAC2 are pertinent to certain cancers and neurodegenerative diseases. Their aberrant activity links to cancer progression influencing genes involved in cell cycle regulation. Overexpression or dysregulation may contribute to the development of cancer types such as leukemia. In neurodegenerative diseases particularly Huntington’s disease abnormal HDAC1 and HDAC2 activity impacts pathways involving neuroplasticity and neuron survival. Shared interactions with proteins like p53 highlight their significance in disease mechanisms.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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