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AB312632

Alexa Fluor® 568 Anti-SULT2A1/ST2 antibody [EPR16096]

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Rabbit Recombinant Monoclonal SULT2A1/ST2 antibody - conjugated to Alexa Fluor® 568.

View Alternative Names

HST, STD, SULT2A1, Sulfotransferase 2A1, ST2A1, Bile salt sulfotransferase, Dehydroepiandrosterone sulfotransferase, Hydroxysteroid Sulfotransferase, ST2, SULT2A3, DHEA-ST, DHEA-ST8

  • Unconjugated

    Anti-SULT2A1/ST2 antibody [EPR16096]

  • 578 PE

    PE Anti-SULT2A1 antibody [EPR16096]

  • 660 APC

    APC Anti-SULT2A1 antibody [EPR16096]

  • HRP

    HRP Anti-SULT2A1 antibody [EPR16096]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-SULT2A1 antibody [EPR16096]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-SULT2A1 antibody [EPR16096]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-SULT2A1 antibody [EPR16096]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-SULT2A1 antibody [EPR16096]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-SULT2A1/ST2 antibody [EPR16096]

  • Carrier free

    Anti-SULT2A1/ST2 antibody [EPR16096] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR16096

Isotype

IgG

Conjugation

Alexa Fluor® 568

Excitation/Emission

Ex: 578nm, Em: 603nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Bile Acid Assay Kit (Colorimetric)

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SULT2A1 also known as ST2 is an enzyme belonging to the sulfotransferase family. It mechanically transfers sulfate groups to hydroxy steroids which include substances like dehydroepiandrosterone (DHEA) as well as other sterols. SULT2A1 exhibits an approximate molecular mass of 34 kDa. Expression occurs mainly in the liver and adrenal glands where it plays important role in steroid metabolism. It is also found in the intestine and skin although at lower levels. This enzyme's function in these tissues suggests its involvement in the local regulation of hormone action and metabolism.
Biological function summary

The role of SULT2A1 extends to the regulation of hormones by sulfurylation which makes compounds more soluble and ready for excretion. This process effectively deactivates certain steroid hormones thereby modulating their activity within the body. SULT2A1 does not typically form part of a larger complex but works independently in modifying steroid substrates. The enzyme's activity allows for regulation of hormone availability and subsequently holds substantial influence over multiple physiological processes.

Pathways

SULT2A1 is active in the steroid metabolism and catabolic pathways. It functions alongside other enzymes like CYP3A4 a cytochrome P450 enzyme to transform and clear hormone derivatives from the body. This cooperation is important for maintaining hormonal balance by converting active hormones into less active forms or preparing them for elimination. SULT2A1 contributes specifically to the homeostasis of androgen and estrogen metabolism through the sulfate conjugation pathway regulating the sensitivity of tissues to these hormones.

Alterations in SULT2A1 activity have connections with adrenal diseases and certain forms of cancer. Overactive or deficient SULT2A1 enzyme function can disrupt hormone levels affecting conditions like congenital adrenal hyperplasia. This condition involves hormone imbalances due to enzyme irregularities upstream where SULT2A1's role in sulfate conjugation remains integral. It is also associated with breast cancer where enzyme interactions with estrogen derivatives might modulate proliferative signals; related proteins include estrogen receptor pathways that influence tumor growth. Understanding SULT2A1's function in these contexts aids in grasping the broader impact of hormone regulation and metabolism in disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed : 14573603, PubMed : 18042734, PubMed : 19589875, PubMed : 21187059, PubMed : 2268288, PubMed : 29671343, PubMed : 7678732, PubMed : 7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed : 14573603, PubMed : 19589875, PubMed : 21187059). Plays a key role in bile acid metabolism (PubMed : 2268288). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
See full target information SULT2A1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

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Alternative Version
Primary Antibodies

AB240333

Anti-SULT2A1/ST2 antibody [EPR16096] - BSA and Azide free

primary-antibodies

sult2a1-st2-antibody-epr16096-bsa-and-azide-free-ab240333

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