Alexa Fluor® 568 Anti-Tau (phospho T231) antibody [EPR2488]
- RabMAb
- Recombinant
- What is this?
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Rabbit Recombinant Monoclonal TAU phospho T231 antibody - conjugated to Alexa Fluor® 568.
View Alternative Names
MAPTL, MTBT1, TAU, MAPT, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
Related conjugates and formulations (7)
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Anti-Tau (phospho T231) antibody [EPR2488]
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Anti-Tau (phospho T231) antibody [EPR2488] - BSA and Azide free
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665 Alexa Fluor® 647
Alexa Fluor® 647 Anti-Tau (phospho T231) antibody [EPR2488]
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519 Alexa Fluor® 488
Alexa Fluor® 488 Anti-Tau (phospho T231) antibody [EPR2488]
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565 Alexa Fluor® 555
Alexa Fluor® 555 Anti-Tau (phospho T231) antibody [EPR2488]
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617 Alexa Fluor® 594
Alexa Fluor® 594 Anti-Tau (phospho T231) antibody [EPR2488]
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775 Alexa Fluor® 750
Alexa Fluor® 750 Anti-Tau (phospho T231) antibody [EPR2488]
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Why is this recommended?
We recommend this product because it’s often used in the same experiment or related research.
We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.
Product details
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
Properties and storage information
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Purification technique
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Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Tau is involved in the assembly and stabilization of microtubules essential for maintaining neuronal structure. It interacts with microtubule-binding domains (MBD) to bind and bundle microtubules facilitating intracellular transport. Tau forms a part of the neuronal cytoskeleton complex working closely with other cytoskeletal proteins to preserve the proper axonal transport and function. Abnormally phosphorylated Tau often termed phospho-Tau disrupts this complex affecting microtubule stability.
Pathways
Tau has critical involvement in several signaling cascades such as the microtubule-binding and transport pathways. Glycogen synthase kinase 3 beta (GSK3β) and cyclin-dependent kinase 5 (CDK5) frequently phosphorylate Tau controlling its interaction with microtubules. Phosphorylated Tau accumulates leading to the formation of neurofibrillary tangles often observed in neurodegenerative conditions. Additionally Tau interacts with GAPDH impacting cellular energy regulation through potential pathway cross-talk involving oxidative stress responses.
Product protocols
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Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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