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AB312503

Alexa Fluor® 568 Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

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Rabbit Recombinant Monoclonal TCEA1 antibody - conjugated to Alexa Fluor® 568.

View Alternative Names

GTF2S, TFIIS, TCEA1, Transcription elongation factor A protein 1, Transcription elongation factor S-II protein 1, Transcription elongation factor TFIIS.o

  • Unconjugated

    Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 660 APC

    APC Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • HRP

    HRP Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 578 PE

    PE Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821]

  • Carrier free

    Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14821

Isotype

IgG

Conjugation

Alexa Fluor® 568

Excitation/Emission

Ex: 578nm, Em: 603nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TCEA1 also known as transcription elongation factor A protein 1 or TFIIS plays a mechanical role in the process of transcription elongation. This protein has a molecular mass of approximately 34 kDa. TCEA1 is expressed in a wide range of tissues indicating a broad involvement in cellular functions. During transcription elongation TCEA1 interacts with RNA polymerase II helping to reactivate stalled enzyme complexes by promoting cleavage of backtracked RNA which is essential to maintain transcription fidelity.
Biological function summary

TCEA1 is important for the proper regulation and efficiency of gene expression. It is not part of a large complex but interacts specifically with RNA polymerase II to facilitate transcript elongation. Without TCEA1 cells may experience transcription arrest either temporarily or permanently which can lead to aberrant gene expression profiles. It ensures continuity in transcription so that the full-length RNA transcripts are synthesized without interruption which is necessary for correct cellular function.

Pathways

TCEA1 plays an indispensable role in the transcription machinery pathway and is closely related to components like RNA polymerase II and TFIIH within the transcription cycle. It is also connected to the DNA damage response pathways because it allows resumption of transcription after damage repair. These pathways maintain cellular homeostasis and balance gene expression to adapt to cellular needs and external signals. Together with other transcription factors TCEA1 ensures transcriptional regulation in response to cellular stimuli.

TCEA1 is implicated in transcription-related diseases such as neurodegenerative disorders and cancer. Mutations or dysregulation of TCEA1 can lead to impaired transcription which often results in cellular malfunction and disease progression. It is associated with proteins like p53 in cancer pathways where transcription arrest and restart mechanisms play a critical part in controlling cell growth and apoptosis. In neurodegenerative diseases disruption of transcriptional processes leads to neuronal cell damage and death contributing to the pathogenesis of these disorders. Understanding the role of TCEA1 in these pathways provides critical insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
See full target information TCEA1

Additional targets

TCEA2,TCEA3
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Version
Primary Antibodies

AB242405

Anti-TCEA1 + TCEA2 + TCEA3 antibody [EPR14821] - BSA and Azide free

primary-antibodies

tcea1-tcea2-tcea3-antibody-epr14821-bsa-and-azide-free-ab242405

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