Rabbit Recombinant Monoclonal 5HT3A receptor/5ht3 antibody - conjugated to Alexa Fluor® 594.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
5ht3, Htr3, Htr3a, 5-hydroxytryptamine receptor 3A, 5-HT3-A, 5-HT3A, 5-hydroxytryptamine receptor 3, Serotonin receptor 3A, Serotonin-gated ion channel receptor, 5-HT-3, 5-HT3R
Rabbit Recombinant Monoclonal 5HT3A receptor/5ht3 antibody - conjugated to Alexa Fluor® 594.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
The 5HT3A receptor also known as the 5-HT3 receptor or 5HT3 forms part of the serotonin receptor family. These ligand-gated ion channels enable the rapid conduction of cations such as Na+ and Ca2+ into cells upon activation. The 5-HT3A receptor exhibits a molecular weight of approximately 55 to 60 kDa and is expressed broadly in peripheral and central nervous systems including regions like the cortex hippocampus and gastrointestinal tract. This expression pattern allows it to perform roles in neurotransmission and modulate physiological responses across different systems.
The 5-HT3A receptor acts as a critical mediator of synaptic signalling and neurotransmitter release offering a path for serotonin's effects. As part of a pentameric complex 5-HT3A subunits combine to form functional ion channels. The receptor particularly influences excitatory neurotransmission affecting processes involved in mood regulation nausea and vomiting. Consequently this receptor serves key physiological functions through its modulation of ionic flux and neuronal activity.
The 5-HT3A receptor plays an essential role in pathways related to neurotransmission and neuroplasticity. Within serotonin signalling pathways 5HT3A closely associates with proteins such as serotonin transporter (SERT) elaborating on its role in serotonin uptake and homeostasis. Furthermore its participation in these pathways links to the regulation of calcium-dependent processes interacting with calmodulins and other calcium-binding proteins to influence downstream signalling events essential for cognitive processes and sensory signalling.
The 5-HT3A receptor has been associated with conditions like anxiety and irritable bowel syndrome (IBS). In anxiety disorders its role in modulating serotonin-induced neurotransmission points to its involvement in mood disorders where altered serotonin balance is a contributing factor. As for IBS the receptor's high expression in the gut highlights its influence on gastrointestinal motility and secretion. Researchers also explore its connection with GABAergic systems pointing to potential therapeutic targets for managing symptoms in these disorders.
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We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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