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AB310686

Alexa Fluor® 594 Anti-ATE1 antibody [EPR13667(2)] - N-terminal

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Rabbit Recombinant Monoclonal ATE1 antibody - conjugated to Alexa Fluor® 594.

View Alternative Names

Arginyl-tRNA--protein transferase 1, Arginyltransferase 1, R-transferase 1, Arginine-tRNA--protein transferase 1, ATE1

  • 578 PE

    PE Anti-ATE1 antibody [EPR13667(2)] (N-terminal)

  • 660 APC

    APC Anti-ATE1 antibody [EPR13667(2)] (N-terminal)

  • HRP

    HRP Anti-ATE1 antibody [EPR13667(2)] (N-terminal)

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-ATE1 antibody [EPR13667(2)] - N-terminal

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-ATE1 antibody [EPR13667(2)] - N-terminal

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-ATE1 antibody [EPR13667(2)] - N-terminal

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-ATE1 antibody [EPR13667(2)] - N-terminal

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-ATE1 antibody [EPR13667(2)] - N-terminal

  • Unconjugated

    Anti-ATE1 antibody [EPR13667(2)] - N-terminal

  • Carrier free

    Anti-ATE1 antibody [EPR13667(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13667(2)

Isotype

IgG

Conjugation

Alexa Fluor® 594

Excitation/Emission

Ex: 590nm, Em: 617nm

Carrier free

No

Applications

Target Binding Affinity, Antibody Labelling

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATE1 also known as Arginyltransferase 1 is an important enzyme that plays a mechanical role in cellular processes. It is responsible for adding the amino acid arginine to the N-terminus of certain target proteins a modification important for protein stability and function. ATE1 has a molecular mass of approximately 75 kDa. This enzyme is expressed in various tissues with higher expression levels observed in the heart liver and brain indicating its importance in these areas.
Biological function summary

ATE1 acts as a regulator in protein degradation by tagging proteins with arginine marking them for ubiquitination and subsequent proteasomal degradation. This function is critical for controlling the protein turnover and maintaining cellular homeostasis. ATE1 functions independently and is not known to be a part of any larger protein complex emphasizing its specific role in post-translational modification of proteins.

Pathways

This arginylation process by ATE1 integrates into the ubiquitin-proteasome system a pathway significant for protein catabolism. It plays a role in cellular stress responses linking closely with the protein degradation pathways to control damaged or misfolded proteins. ATE1's activity interacts with proteins such as ubiquitin ligases which assist in the tagging and recognition of proteins for degradation ensuring proper proteostasis.

ATE1 has been implicated in cardiac hypertrophy and cancer. Altered expression or activity of ATE1 can contribute to the dysregulation of protein turnover in the heart connecting it to cardiac hypertrophy. In cancer abnormal arginylation can affect cellular homeostasis and lead to uncontrollable cell proliferation. ATE1 connects to proteins like N-end rule substrates in the context of these diseases acting as a potential biomarker or therapeutic target for disease intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed : 34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed : 34893540). Does not arginylate cysteine residues (By similarity).
See full target information ATE1
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