Alexa Fluor® 594 Anti-CD8 antibody [SP239]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

CD8 plays a significant role in the adaptive immune response. It is not part of a multimeric complex but functions as a co-receptor that enhances the recognition of antigens by the T cell receptor (TCR). The presence of CD8 molecules aids the activation of T cells leading to their proliferation and the effective targeting and elimination of pathogens or abnormal cells. The ability of CD8 to bind to MHC class I molecules allows cytotoxic T cells to detect and respond to nearly all nucleated cells in the body.

Pathways

CD8 is integral in both the T cell receptor signaling pathway and the induction of apoptosis. In the T cell receptor signaling pathway CD8 works closely with other proteins like Lck and ZAP-70 to transmit signals upon TCR-MHC class I engagement. This promotes T cell activation cytokine production and cell division. Furthermore CD8's interaction with Fas ligand pathways contributes to the initiation of programmed cell death which is important for maintaining immune homeostasis and preventing overreaction of the immune system.