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AB310585

Alexa Fluor® 594 Anti-NAGLU antibody [EPR20708]

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Rabbit Recombinant Monoclonal NAGLU/NAG antibody - conjugated to Alexa Fluor® 594.

View Alternative Names

UFHSD1, NAGLU, Alpha-N-acetylglucosaminidase, N-acetyl-alpha-glucosaminidase, NAG

  • Unconjugated

    Anti-NAGLU/NAG antibody [EPR20708]

  • 578 PE

    PE Anti-NAGLU/NAG antibody [EPR20708]

  • HRP

    HRP Anti-NAGLU/NAG antibody [EPR20708]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-NAGLU/NAG antibody [EPR20708]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-NAGLU antibody [EPR20708]

  • 660 APC

    APC Anti-NAGLU/NAG antibody [EPR20708]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-NAGLU/NAG antibody [EPR20708]

  • Carrier free

    Anti-NAGLU/NAG antibody [EPR20708] - BSA and Azide free

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-NAGLU antibody [EPR20708]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-NAGLU antibody [EPR20708]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR20708

Isotype

IgG

Conjugation

Alexa Fluor® 594

Excitation/Emission

Ex: 590nm, Em: 617nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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N-Acetylglucosaminidase (beta-NAG) Activity Assay Kit (Colorimetric)

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Product details

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NAGLU/NAG also known as alpha-N-acetylglucosaminidase is an enzyme with a molecular weight of approximately 83 kDa. This enzyme localizes in the lysosome where cells express it across various tissues. NAGLU plays a significant role in the breakdown of heparan sulfate which is a glycosaminoglycan found on cell surfaces and in the extracellular matrix. Its enzymatic action involves the cleavage of terminal alpha-N-acetylglucosamine residues during lysosomal degradation.
Biological function summary

NAGLU facilitates the degradation of heparan sulfate in conjunction with other enzymes as part of a degradation complex within the lysosome. NAGLU's action is essential for maintaining the balance of heparan sulfate levels inside cells which is important for cellular health and function. Without the proper function of this enzyme heparan sulfate accumulates within lysosomes due to incomplete catabolism leading to cellular dysfunction and related pathologies.

Pathways

NAGLU functions critically in the glycosaminoglycan degradation pathway. This pathway involves several enzymes including iduronate-2-sulfatase which acts upstream of NAGLU. Together they ensure the breakdown of complex sugars such as heparan sulfate. NAGLU also participates in the larger lysosomal degradation pathway collaborating with other lysosomal enzymes to ensure proper breakdown and recycling of cellular materials.

Disruptions in NAGLU function are directly linked to mucopolysaccharidosis type IIIB (MPS IIIB) also known as Sanfilippo syndrome type B. This disorder results from mutations that impair NAGLU activity causing heparan sulfate accumulation and neurodegeneration. Additionally deficient NAGLU activity may intersect with pathologies involving heparan sulfate binding proteins impacting cellular signaling and contributing to disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the degradation of heparan sulfate.
See full target information NAGLU
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Version
Primary Antibodies

AB251547

Anti-NAGLU/NAG antibody [EPR20708] - BSA and Azide free

primary-antibodies

naglu-nag-antibody-epr20708-bsa-and-azide-free-ab251547

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(0 reviews)

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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