Rabbit Recombinant Monoclonal PHYHD1 antibody - conjugated to Alexa Fluor® 594.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner (PubMed:21530488). However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism (PubMed:21530488). Does not show detectable activity towards fatty acid CoA thioesters (PubMed:21530488). Isoform 2. Isoform 2 probably lacks enzyme activity. Isoform 3. Isoform 3 probably lacks enzyme activity.
Phytanoyl-CoA dioxygenase domain-containing protein 1, Protein PHYHD1, PHYHD1
Rabbit Recombinant Monoclonal PHYHD1 antibody - conjugated to Alexa Fluor® 594.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
The PHYHD1 protein also known as Phytanoyl-CoA Dioxygenase Domain Containing 1 functions as an enzyme involved in metabolic processes. It carries out oxidation reactions specifically hydroxylation on specific substrate molecules. PHYHD1 has a molecular mass of approximately 44 kDa making it a moderate-sized protein. Expressed in various tissues including the liver and kidneys PHYHD1 plays a significant role in managing metabolic activity within these regions contributing to cellular homeostasis and overall metabolic health.
PHYHD1 participates in cellular metabolism by catalyzing reactions that modify fatty acids. This protein is involved in the breakdown of phytanic acid a complex fatty acid. In these reactions PHYHD1 may function independently or as part of larger protein complexes facilitating intricate steps that convert fatty acids into more usable forms. This process represents a significant part of lipid metabolism illustrating PHYHD1's role in maintaining the balance of lipid levels and energy within the cell.
Researchers identified PHYHD1 in pathways related to fatty acid metabolism and chain elongation. In the context of the peroxisomal alpha-oxidation pathway PHYHD1 interacts with important proteins such as Peroxin and Phytanoyl-CoA alpha-hydroxylase which together assist in processing certain fatty acids. Additionally PHYHD1 links to other metabolic pathways involving oxidation reactions highlighting its central role in modulating lipid and energy metabolism.
Studies associate PHYHD1 with conditions such as Refsum Disease and disorders of fatty acid metabolism. Refsum Disease a genetic disorder involving the accumulation of phytanic acid sees a loss or reduction in PHYHD1 activity leading to severe symptoms. Through these associations PHYHD1 interacts with proteins like the phytanoyl-CoA hydroxylase enzyme exemplifying its critical role in the breakdown of fatty acids and linking its activity directly to disease state development and progression.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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