Rabbit Recombinant Monoclonal Radixin/RDX antibody - conjugated to Alexa Fluor® 594.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Radixin, RDX
Rabbit Recombinant Monoclonal Radixin/RDX antibody - conjugated to Alexa Fluor® 594.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
Radixin also known as RDX is a member of the ezrin-radixin-moesin (ERM) family of proteins. It weighs approximately 68 kDa and is expressed in a variety of tissues with high levels found in the brain liver and intestines. Radixin functions mechanically by binding to actin filaments and linking them to the plasma membrane. This process is essential for maintaining cell shape and facilitating signal transduction.
Radixin plays a role in modulating cell surface structure which influences microvilli formation and stability. Radixin serves as a linkage between the actin cytoskeleton and the plasma membrane which helps in forming actin-rich surface structures. It does not function alone; it often acts as part of larger complexes that control cytoskeleton-related activities. Its role in maintaining cellular architecture makes it integral to processes like cell adhesion migration and polarization.
Radixin is an important component in signaling pathways that regulate the cytoskeleton and cell membrane interactions. Key pathways include the Rho family of GTPases and the PI3K/Akt pathway. Radixin interacts with these pathways by connecting with proteins such as RhoA which regulates actin dynamics and Akt which influences cell survival and growth. These interactions are important for cellular responses to environmental and internal signals.
Improper function of radixin relates to certain pathological conditions including hepatocellular carcinoma and cholestasis. In hepatocellular carcinoma radixin impacts cell proliferation and migration making it a potential target for cancer therapy. In cholestasis radixin dysfunction has connections with altered bile canalicular structures often interacting with proteins like CFTR. These associations highlight its significance as a potential target for therapeutic strategies aiming to correct cellular structures in these disorders.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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