Rabbit Recombinant Monoclonal ALDH1L1 antibody - conjugated to Alexa Fluor® 647.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Application | Reactivity | Dilution info | Notes |
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Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).
Mitochondrial 10-formyltetrahydrofolate dehydrogenase
FTHFD, ALDH1L1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1
Rabbit Recombinant Monoclonal ALDH1L1 antibody - conjugated to Alexa Fluor® 647.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
ALDH1L1 and ALDH1L2 also called 10-formyltetrahydrofolate dehydrogenases are enzymes involved in folate metabolism. The enzymes have molecular masses of approximately 110 kDa. They are predominantly expressed in astrocytes in the central nervous system. ALDH1L1 is widely recognized as an astrocyte marker due to its specific expression pattern in these glial cells in the brain. The enzyme plays a role in one-carbon metabolism necessary for synthesizing nucleotides and other cellular processes.
ALDH1L1 and ALDH1L2 participate in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate. This reaction is important for the regulation of cellular one-carbon units. They function as part of the folate metabolic pathway often interacting with proteins like methylene tetrahydrofolate reductase. As an important regulator in folate metabolism ALDH1L1 particularly serves as an astrocyte marker which helps in identifying these cells within the brain tissue.
ALDH1L1 and ALDH1L2 are important components of the folate and methionine cycles. These cycles play a significant role in cell growth and proliferation. Within the methionine cycle ALDH1L1 interacts with proteins like methionine synthase facilitating methionine regeneration from homocysteine. This connection highlights the enzymes' integrative role in maintaining cellular methylation and genetic expression through their metabolic functions.
Disturbances in ALDH1L1 and ALDH1L2 activity can link to neurological conditions such as Alzheimer's disease and epilepsy. ALDH1L1 as an astrocyte marker is often researched in the context of neuroinflammation and neurodegeneration. Dysregulation in folate metabolism may affect homocysteine levels potentially connecting ALDH1L1 with proteins such as S-adenosylhomocysteine hydrolase in these diseases. Understanding these enzymes' role in disease pathways offers potential therapeutic targets for related disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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