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Rabbit Recombinant Monoclonal ALDH1L1 antibody - conjugated to Alexa Fluor® 647.

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Key facts

Isotype
IgG
Host species
Rabbit
Conjugation
Alexa Fluor® 647
Excitation/Emission
Ex: 650nm, Em: 665nm
Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Application
Target Binding Affinity
Reactivity
Expected
Dilution info
-
Notes

-

Application
Antibody Labelling
Reactivity
Expected
Dilution info
-
Notes

-

Associated Products

Select an associated product type

1 product for Alternative Version

Target data

Function

Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).

Additional Targets

Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Alternative names

Rabbit Recombinant Monoclonal ALDH1L1 antibody - conjugated to Alexa Fluor® 647.

Key facts

Isotype
IgG
Conjugation
Alexa Fluor® 647
Excitation/Emission
Ex: 650nm, Em: 665nm
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR12743(B)
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle, Store in the dark

Notes

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

ALDH1L1 and ALDH1L2 also called 10-formyltetrahydrofolate dehydrogenases are enzymes involved in folate metabolism. The enzymes have molecular masses of approximately 110 kDa. They are predominantly expressed in astrocytes in the central nervous system. ALDH1L1 is widely recognized as an astrocyte marker due to its specific expression pattern in these glial cells in the brain. The enzyme plays a role in one-carbon metabolism necessary for synthesizing nucleotides and other cellular processes.

Biological function summary

ALDH1L1 and ALDH1L2 participate in the conversion of 10-formyltetrahydrofolate to tetrahydrofolate. This reaction is important for the regulation of cellular one-carbon units. They function as part of the folate metabolic pathway often interacting with proteins like methylene tetrahydrofolate reductase. As an important regulator in folate metabolism ALDH1L1 particularly serves as an astrocyte marker which helps in identifying these cells within the brain tissue.

Pathways

ALDH1L1 and ALDH1L2 are important components of the folate and methionine cycles. These cycles play a significant role in cell growth and proliferation. Within the methionine cycle ALDH1L1 interacts with proteins like methionine synthase facilitating methionine regeneration from homocysteine. This connection highlights the enzymes' integrative role in maintaining cellular methylation and genetic expression through their metabolic functions.

Associated diseases and disorders

Disturbances in ALDH1L1 and ALDH1L2 activity can link to neurological conditions such as Alzheimer's disease and epilepsy. ALDH1L1 as an astrocyte marker is often researched in the context of neuroinflammation and neurodegeneration. Dysregulation in folate metabolism may affect homocysteine levels potentially connecting ALDH1L1 with proteins such as S-adenosylhomocysteine hydrolase in these diseases. Understanding these enzymes' role in disease pathways offers potential therapeutic targets for related disorders.

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