Rabbit Recombinant Monoclonal ATP synthase C antibody - conjugated to Alexa Fluor® 647.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
ATP5G1, ATP5MC1, ATP synthase lipid-binding protein, ATP synthase membrane subunit c locus 1, ATP synthase proteolipid P1, ATP synthase proton-transporting mitochondrial F(0) complex subunit C1, ATPase protein 9, ATPase subunit c
Rabbit Recombinant Monoclonal ATP synthase C antibody - conjugated to Alexa Fluor® 647.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
ATP5G1 ATP5G2 and ATP5G3 also known as subunits c of the mitochondrial ATP synthase are integral components of the F0 membrane sector of ATP synthase. These proteins have a mass of approximately 8.2 kilodaltons and play an important role in the proton-conducting pore of the enzyme. Expression occurs mainly in tissues with high energy demands such as cardiac and skeletal muscles. As integral membrane proteins they anchor as oligomers in the inner mitochondrial membrane and participate in the process of ATP production.
ATP5G1 ATP5G2 and ATP5G3 form part of the ATP synthase complex which is essential for oxidative phosphorylation and cellular energy production. The ATP synthase complex consists of two main parts: F1 and F0. The subunits c encoded by ATP5G1 ATP5G2 and ATP5G3 construct a rotary motor within the F0 complex that allows proton translocation across the inner mitochondrial membrane. This process facilitates the production of ATP from ADP and inorganic phosphate which is the primary energy currency of the cell.
ATP5G1 ATP5G2 and ATP5G3 subunits participate in the oxidative phosphorylation pathway an important component of cellular respiration. This pathway plays a major role in energy generation by creating ATP through electron transport and chemiosmotic coupling mechanisms. The ATP synthase complex works in conjunction with other proteins like cytochrome c oxidase in the electron transport chain. Efficient functioning of these proteins ensures ATP production which is vital for various cellular processes.
Defects or malfunctions in ATP5G1 ATP5G2 and ATP5G3 have associations with mitochondrial disorders and neuromuscular diseases. Dysfunction in the ATP synthase complex can lead to conditions such as Leigh syndrome and other mitochondrial encephalomyopathies. The subunits are also connected with proteins involved in these disorders including the adenine nucleotide translocase. Understanding these relationships helps in diagnosing and developing therapeutic strategies for these energy deficiency-related conditions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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