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Mouse Monoclonal CD200 / OX2 antibody - conjugated to Alexa Fluor® 647. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.

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Images

Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (AB270662), expandable thumbnail
  • Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (AB270662), expandable thumbnail
  • Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (AB270662), expandable thumbnail

Key facts

Isotype
IgG1
Host species
Mouse
Conjugation
Alexa Fluor® 647
Excitation/Emission
Ex: 650nm, Em: 665nm
Storage buffer

pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information. Database link P41217

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species
Human
Dilution info
-
Notes

-

Target data

Function

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Alternative names

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

Recommended products

Mouse Monoclonal CD200 / OX2 antibody - conjugated to Alexa Fluor® 647. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.

Key facts

Isotype
IgG1
Conjugation
Alexa Fluor® 647
Excitation/Emission
Ex: 650nm, Em: 665nm
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information. Database link P41217
Clone number
OX-104
Purification technique
Size-exclusion chromatography
Epitope
extracellular
Light chain type
kappa
Concentration
Loading...
Purification notes

Purified from Tissue culture supernatant.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze

Notes

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

Associated diseases and disorders

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

Product promise

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3 product images

  • Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (ab270662), expandable thumbnail

    Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (ab270662)

    Separation of human CD200 positive CD3 negative lymphocytes (Red) from CD200 negative T-cells (black-dashed) in flow cytometric analysis labeling CD200 using ab270662. (4 μl reagent / 100 μl of peripheral whole blood).

  • Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (ab270662), expandable thumbnail

    Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (ab270662)

    Flow cytometric analysis of human lymphocytes labeling CD200 with ab270662 at 4μl reagent /100 μl of peripheral whole blood and an anti-human CD3 (UCHT1) PE antibody (20 μl reagent / 100 μl of peripheral whole blood).

  • Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (ab270662), expandable thumbnail

    Flow Cytometry - Alexa Fluor® 647 Anti-CD200 / OX2 antibody [OX-104] (ab270662)

    Flow cytometric analysis of human peripheral whole blood labeling CD200 with ab270662 at 4 μl reagent / 100 μl of peripheral whole blood.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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