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AB319676

Alexa Fluor® 647 Anti-OTP antibody [EPR22178-17]

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Rabbit Recombinant Monoclonal OTP antibody - conjugated to Alexa Fluor® 647.

View Alternative Names

Homeobox protein orthopedia, OTP

  • 660 APC

    APC Anti-OTP antibody [EPR22178-17]

  • 578 PE

    PE Anti-OTP antibody [EPR22178-17]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-OTP antibody [EPR22178-17]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-OTP antibody [EPR22178-17]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-OTP antibody [EPR22178-17]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-OTP antibody [EPR22178-17]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR22178-17

Isotype

IgG

Conjugation

Alexa Fluor® 647

Excitation/Emission

Ex: 650nm, Em: 665nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OTP also known as orthopedia homeobox is a transcription factor involved in the development and differentiation of neuroendocrine cells. It belongs to the homeobox family of proteins which are characterized by a specific DNA-binding domain. OTP typically weighs around 35 kDa. This protein is mainly expressed in the central nervous system and neuroendocrine tissues particularly within the hypothalamus.
Biological function summary

OTP plays an important role in the regulation of gene expression during the development of specific neuronal cell types. It is not part of a larger complex but interacts with various other transcription factors to influence cell fate decisions. OTP's regulatory actions are essential during embryonic development where it directs the differentiation and specialization of neurons.

Pathways

OTP is significant in the development pathways of the nervous system. It participates in neurogenesis particularly influencing the hypothalamic lineage. OTP interacts with proteins such as Nkx2.1 and Sim1 which are also transcription factors that guide the specification of neuroendocrine neurons. These interactions highlight OTP’s involvement in complex genetic regulatory networks essential for proper nervous system function.

OTP shows relevance to certain neurodevelopmental disorders and tumors. Abnormal OTP expression links to the development of medullary thyroid carcinoma a type of cancer affecting thyroid gland cells. Furthermore OTP's expression patterns can aid in distinguishing certain tumor types in neuropathology. Researchers study its interaction with proteins like RET which is also implicated in thyroid cancer to better understand and treat these diseases.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Probably involved in the differentiation of hypothalamic neuroendocrine cells.
See full target information OTP

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com