Rabbit Recombinant Monoclonal OTP antibody - conjugated to Alexa Fluor® 647.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Probably involved in the differentiation of hypothalamic neuroendocrine cells.
Homeobox protein orthopedia, OTP
Rabbit Recombinant Monoclonal OTP antibody - conjugated to Alexa Fluor® 647.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
OTP also known as orthopedia homeobox is a transcription factor involved in the development and differentiation of neuroendocrine cells. It belongs to the homeobox family of proteins which are characterized by a specific DNA-binding domain. OTP typically weighs around 35 kDa. This protein is mainly expressed in the central nervous system and neuroendocrine tissues particularly within the hypothalamus.
OTP plays an important role in the regulation of gene expression during the development of specific neuronal cell types. It is not part of a larger complex but interacts with various other transcription factors to influence cell fate decisions. OTP's regulatory actions are essential during embryonic development where it directs the differentiation and specialization of neurons.
OTP is significant in the development pathways of the nervous system. It participates in neurogenesis particularly influencing the hypothalamic lineage. OTP interacts with proteins such as Nkx2.1 and Sim1 which are also transcription factors that guide the specification of neuroendocrine neurons. These interactions highlight OTP’s involvement in complex genetic regulatory networks essential for proper nervous system function.
OTP shows relevance to certain neurodevelopmental disorders and tumors. Abnormal OTP expression links to the development of medullary thyroid carcinoma a type of cancer affecting thyroid gland cells. Furthermore OTP's expression patterns can aid in distinguishing certain tumor types in neuropathology. Researchers study its interaction with proteins like RET which is also implicated in thyroid cancer to better understand and treat these diseases.
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We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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