Alexa Fluor® 647 Anti-Zic2 antibody [EPR7790]

Supplementary info

Activity summary

Zic2 also called Zinc finger protein of cerebellum 2 represents a transcription factor notable for its role in the regulation of gene expression. Mechanically Zic2 binds to DNA sequences via its zinc finger domains facilitating transcriptional activation or repression depending on the context. This protein has an approximate molecular mass of 60 kDa and exhibits expression mainly in the developing central nervous system. Zic2 shows high levels of expression in postmitotic neurons and various embryonic tissues indicating its involvement in central neural developmental processes.

Biological function summary

Zic2 impacts the differentiation and proliferation of neural progenitor cells. Zic2 functions as part of a transcriptional regulatory complex collaborating with other partners to control genes necessary for neurodevelopment. Its activity supports the specification of neuronal identity and axonal pathfinding. Studies demonstrate its important role in guiding axons to their correct targets a function integral during the formation of neural circuits. Zic2-mediated transcriptional networks are essential for accurate neuronal patterning in the central nervous system.

Pathways

Several interactions revolving around Zic2 play essential roles. Zic2 is involved in the Sonic Hedgehog (Shh) signaling pathway where it contributes to the transcriptional response important for patterning activities. Within the Shh pathway Zic2 interacts with downstream components like Gli proteins which modulate target gene expression based on signal gradient. Additionally Zic2 participates in the Wnt signaling pathway where it influences cell fate determination and tissue polarity. Such pathways highlight its part in developmental processes and cellular differentiation.

Associated diseases and disorders

Mutations or dysregulation of Zic2 often associate with congenital malformations such as holoprosencephaly and mirror movement disorder. These disorders arise from disrupted neural development reflecting Zic2's key roles in morphogenesis and patterning. Both conditions involve abnormal neurodevelopment where altered Zic2 interactions with proteins such as Gli3 result in impaired signaling cascades. Understanding these connections helps clarify Zic2's contribution to pathological states offering insights into potential therapeutic targets.