Rabbit Recombinant Monoclonal Claudin 18 antibody - conjugated to Alexa Fluor® 750.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
The protein expressed by the gene CLDN18 plays a major role in the tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity. This supplementary information is collated from multiple sources and compiled automatically.
UNQ778/PRO1572, CLDN18, Claudin-18
Rabbit Recombinant Monoclonal Claudin 18 antibody - conjugated to Alexa Fluor® 750.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
Claudin18.2 and Claudin18.1 are integral membrane proteins part of the claudin family which are tight junction proteins. Claudin18.2 has a molecular weight of approximately 27 kDa. These proteins are primarily expressed in epithelial cells particularly within the gastric mucosa and lung tissue. They serve as essential components of cell-cell adhesion influencing paracellular transport and maintaining cell polarity.
These proteins are vital in forming tight junction strands contributing to cellular barrier functions. Claudin18.2 and Claudin18.1 belong to a multi-protein complex vital for establishing cell permeability limits. Through their integration in tight junctions they regulate ion passage minimize fluid loss and maintain tissue homeostasis. Their dynamic nature allows adaptation in response to physiological stimuli making them central to epithelial barrier integrity.
Claudins including Claudin18.2 and Claudin18.1 play roles in signaling pathways like Wnt and MAPK which are pivotal for cellular processes like proliferation and differentiation. These pathways involve interactions with proteins like ZO-1 and occludin contributing to the signaling processes across the epithelial cells. This involvement with important signaling proteins highlights their importance in maintaining cell function and signaling responses.
These claudins have strong associations with gastric cancer and asthma pathophysiology. Overexpression of Claudin18.2 has been shown in gastric cancer indicating its potential as a therapeutic target. In asthma altered expression of Claudin18.1 affects lung epithelial integrity linking these proteins to airway inflammation and remodeling. The connection with proteins like E-cadherin and beta-catenin further highlights their role in tumor progression and epithelial transformation making them relevant in clinical research.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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