Rabbit Recombinant Monoclonal SDHC antibody - conjugated to Alexa Fluor® 750.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:9533030). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity).
CYB560, SDH3, SDHC, Integral membrane protein CII-3, Malate dehydrogenase [quinone] cytochrome b560 subunit, QPs-1, Succinate dehydrogenase complex subunit C, Succinate-ubiquinone oxidoreductase cytochrome B large subunit, QPs1, CYBL
Rabbit Recombinant Monoclonal SDHC antibody - conjugated to Alexa Fluor® 750.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
SDHC also known as succinate dehydrogenase complex subunit C or succinate dehydrogenase cytochrome b560 subunit is an integral component of the mitochondrial complex II. It has a mass of approximately 15.3 kDa. SDHC is embedded in the inner mitochondrial membrane and is expressed in various tissues with a high mitochondrial content including skeletal muscle heart and brain. Mechanically SDHC anchors the succinate dehydrogenase (SDH) complex to the mitochondrial membrane facilitating effective electron transport during cellular respiration.
The subunit SDHC plays a role in the conversion of succinate to fumarate in the tricarboxylic acid (TCA) cycle. By being part of the larger succinate dehydrogenase complex which also functions as part of the electron transport chain SDHC contributes to both energy production and metabolic regulation within cells. The SDH complex consists of four subunits: SDHA SDHB SDHC and SDHD. SDHC serving as an integral membrane protein ensures the proper anchoring and assembly of the complex which is essential for efficient electron transfer.
SDHC is involved in both the TCA cycle and the mitochondrial electron transport chain. Within these pathways it enables the transfer of electrons from succinate to ubiquinone connecting two primary bioenergetic pathways. SDHC exhibits a relationship with other complex II subunits such as SDHA which catalyzes the oxidation reaction of succinate to fumarate. The electron flow through SDHC has an impact on the entire process of oxidative phosphorylation ultimately influencing ATP production in cells.
SDHC mutations and dysfunctions have links to conditions such as paragangliomas and pheochromocytomas. These tumors are associated with altered cellular metabolism and abnormal SDH complex activity. Mutations in the SDHC gene can lead to a disruption of normal electron transport chain function causing oxidative stress and contributing to tumorigenesis. Moreover SDHC mutations often co-occur with alterations in other SDH complex components such as SDHB further emphasizing the role of this complex in certain disease states.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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