Alexa Fluor® 750 Anti-SIGIRR antibody [EPR22438-93]
- Recombinant
- RabMAb
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Rabbit Recombinant Monoclonal SIGIRR antibody - conjugated to Alexa Fluor® 750.
View Alternative Names
UNQ301/PRO342, SIGIRR, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8
Related conjugates and formulations (10)
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578 PE
PE Anti-SIGIRR antibody [EPR22438-93]
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660 APC
APC Anti-SIGIRR antibody [EPR22438-93]
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HRP Anti-SIGIRR antibody [EPR22438-93]
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519 Alexa Fluor® 488
Alexa Fluor® 488 Anti-SIGIRR antibody [EPR22438-93]
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665 Alexa Fluor® 647
Alexa Fluor® 647 Anti-SIGIRR antibody [EPR22438-93]
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617 Alexa Fluor® 594
Alexa Fluor® 594 Anti-SIGIRR antibody [EPR22438-93]
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565 Alexa Fluor® 555
Alexa Fluor® 555 Anti-SIGIRR antibody [EPR22438-93]
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603 Alexa Fluor® 568
Alexa Fluor® 568 Anti-SIGIRR antibody [EPR22438-93]
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Anti-SIGIRR antibody [EPR22438-93]
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Anti-SIGIRR antibody [EPR22438-93] - BSA and Azide free
Product details
Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
Properties and storage information
Form
Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SIGIRR modulates immune responses by dampening inflammation and maintaining homeostasis in immune-related pathways. SIGIRR functions as a decoy receptor binding ligands without initiating a signaling cascade which effectively reduces the immune response. It does not work alone; it is part of larger receptor complexes within the TLR and IL-1R family where it can inhibit the signaling of other family members like TLR4 and IL-1R1 thereby controlling their activity and preventing excessive inflammation.
Pathways
SIGIRR participates in both the Toll-like receptor and interleukin-1 receptor pathways. It interacts with adaptor proteins such as MyD88 to modulate the downstream signaling cascade that involves NF-kB activation a central transcription factor in immune response. By doing so it keeps the inflammation response in check connecting to related proteins within these pathways that include IL-1R1 and TLR4 ultimately regulating key pro-inflammatory processes.
Product protocols
- Visit the General protocols
- Visit the Troubleshooting
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com