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AB321112

Alexa Fluor® 750 Anti-WDR68 antibody [EPR8712]

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Rabbit Recombinant Monoclonal WDR68 antibody - conjugated to Alexa Fluor® 750.

View Alternative Names

HAN11, WDR68, DCAF7, DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8712

Isotype

IgG

Conjugation

Alexa Fluor® 750

Excitation/Emission

Ex: 749nm, Em: 775nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR68 also known as DCAF7 or Han11 is a protein with a mass of approximately 40 kDa. It functions mechanically as a scaffold protein facilitating interactions between various signaling molecules. WDR68 is expressed broadly across different tissue types including the brain heart and skeletal muscle. Its role as a scaffold indicates its importance in organizing and stabilizing multi-protein complexes that regulate numerous cellular processes.
Biological function summary

The WDR68 protein interacts with other cellular components to regulate signaling pathways important for cell proliferation and differentiation. It forms a part of the STRIPAK complex which plays a role in modulating developmental processes and cellular stress responses. The protein contributes to the maintenance of cellular structure and function influencing activities like gene expression and signal transduction.

Pathways

WDR68 operates within the MAPK and JNK signaling pathways both of which are essential for transmitting external stimuli to intracellular responses. Within the MAPK pathway WDR68 interacts with kinases such as MAP3Ks facilitating the transduction of mitogenic signals. The JNK pathway involves proteins like MKK4 with WDR68 playing a role in modulating various cellular responses including those involved in apoptosis and stress responses.

WDR68 associates with craniofacial development abnormalities as its interaction with the DYRK1A protein influences cellular signaling during neural crest cell development. Mutations or dysregulations in WDR68 are also linked to cancer progression due to its role in the MAPK pathway affecting cell cycle regulation and apoptosis. The relationship between WDR68 and cancer highlights the involvement of proteins such as MKK4 making it significant in therapeutic research targeting these pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
See full target information DCAF7
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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