Anti-ALG1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The ALG1 protein also known as chitobiosyldiphosphodolichol beta-mannosyltransferase plays an important role in the process of glycoprotein biosynthesis. It has a significant molecular mass of about 47 kDa. ALG1 is prominently expressed in the endoplasmic reticulum. Its function involves the catalysis of mannose transfer making it essential in the formation of glycan chains on proteins.

Biological function summary

ALG1 participates in a larger enzymatic complex responsible for N-glycosylation. This process is important in modifying proteins for proper folding and stability. The protein integrates mannose into lipid-linked oligosaccharides which are then transferred to nascent proteins. ALG1 interacts closely with other enzymes in the glycosylation pathway ensuring the transfer of proper sugar moieties onto proteins.

Pathways

ALG1 operates within the glycosylation and protein quality control pathways. The N-glycosylation pathway relies on ALG1 to add mannose units to dolichol-linked oligosaccharide precursors a necessary step for efficient protein folding. ALG1 links with proteins involved in the calnexin/calreticulin cycle which monitors and assists protein folding and assembly.

Associated diseases and disorders

ALG1 mutations lead to Congenital Disorders of Glycosylation Type Ik (ALG1-CDG) which can cause severe developmental issues and multi-systemic problems. It interacts with proteins in the N-glycosylation process such as ALG2 and ALG5 which can also be implicated in glycosylation disorders. These disorders highlight the importance of ALG1 in maintaining proper cellular function and structure.