AB111121

Anti-ALK-7 antibody

Name: Anti-ALK-7 antibody (ab111121) | Abcam
Brand: Abcam Limited
SKU: AB111121
Price: 535 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal ALK-7 antibody. Suitable for IHC-P, ICC/IF and reacts with Human, African green monkey samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ACVR1C.

View Alternative Names

ALK7, ACVR1C, Activin receptor type-1C, Activin receptor type IC, Activin receptor-like kinase 7, ACTR-IC, ALK-7

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALK-7 antibody (AB111121)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALK-7 antibody (AB111121)

ab111121, at a 1/50 dilution, staining ALK-7 in paraffin embedded human brain tissue by Immunohistochemistry. The image on the right is from cells treated with the synthesized peptide.

Immunocytochemistry/ Immunofluorescence - Anti-ALK-7 antibody (AB111121)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ALK-7 antibody (AB111121)

Immunofluorescence analysis of ALK-7 in COS7 cells, using ab111121 at a 1/100 dilution. The imge on the right is from cells treated with the synthesized peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human, African green monkey

Applications

ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human ACVR1C. The exact immunogen used to generate this antibody is proprietary information.

Q8NER5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab111121 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALK-7 also known as Activin receptor-like kinase 7 is a type I receptor serine/threonine kinase. It has a molecular mass of approximately 58 kDa. ALK-7 is primarily expressed in the central nervous system pancreatic islets and adipose tissue. This protein plays a mechanical role as a receptor that binds to ligands like Nodal which initiates signaling through phosphorylation events essential for cellular communication and regulation.

Biological function summary

ALK-7 participates in the regulation of metabolic processes. It functions by forming a receptor complex with type II receptors upon ligand binding transmitting signals that modulate cellular responses. ALK-7's signaling is important in maintaining glucose homeostasis and energy balance within tissues. Additionally the activity of ALK-7 influences the differentiation of neural cells and the development of adipose tissue illustrating its multifaceted biological roles.

Pathways

The signaling of ALK-7 integrates into the TGF-beta/Activin signaling pathway and the Nodal signaling pathway. Within these pathways it associates functionally with proteins such as SMAD2/3 which facilitate the transmission of extracellular signals to the nucleus resulting in gene expression changes. These pathways are significant for developmental processes and cellular metabolism regulation where ALK-7 contributes to signal transduction necessary for physiological adaptations.

ALK-7 has associations with metabolic syndromes like type 2 diabetes and obesity. Altered ALK-7 signaling affects insulin sensitivity and glucose metabolism linking it to the pathophysiology of these conditions. Furthermore its interaction with Nodal and other factors in related pathways suggests a potential therapeutic target for mitigating metabolic dysfunctions associated with these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

See full target information ACVR1C

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 21:402 PubMed33717261

2021

Biological effects of NODAL on endometrial cancer cells and its underlying mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoshan Hong,Bin Wen,Huaming Zhang,Yuhan Li,Hengying Wu,Wei Zhao,Xiping Luo

Journal of cellular physiology 235:5649-5665 PubMed31960436

2020

Resistance training-induced muscle hypertrophy is mediated by TGF-β1-Smad signaling pathway in male Wistar rats.

Applications

Unspecified application

Species

Unspecified reactive species

Rohollah Nikooie,Sohil Jafari-Sardoie,Vahid Sheibani,Amir Nejadvaziri Chatroudi

Clinical and experimental pharmacology & physiology 47:313-321 PubMed31608496

2019

Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Shi,Xiaomin Dong,Ming Zhang,Yuhong Cheng,Cheng Pei

Oncology reports 39:2855-2864 PubMed29693169

2018

Nodal induced by hypoxia exposure contributes to dacarbazine resistance and the maintenance of stemness in melanoma cancer stem‑like cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Li,Junjie Chen,Xiao Wang,Mei He,Zhenyu Zhang,Ying Cen

Scientific reports 8:1561 PubMed29367682

2018

Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps.

Applications

Unspecified application

Species

Unspecified reactive species

Lotta Tengroth,Julia Arebro,Olivia Larsson,Claus Bachert,Susanna Kumlien Georén,Lars-Olaf Cardell

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ALK-7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALK-7 antibody (AB111121)

Immunocytochemistry/ Immunofluorescence - Anti-ALK-7 antibody (AB111121)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

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