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AB77051

Anti-ALK-7 antibody - N-terminal

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(2 Publications)

Rabbit Polyclonal ALK-7 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ACVR1C.

View Alternative Names

ALK7, ACVR1C, Activin receptor type-1C, Activin receptor type IC, Activin receptor-like kinase 7, ACTR-IC, ALK-7

1 Images
Western blot - Anti-ALK-7 antibody - N-terminal (AB77051)
  • WB

Unknown

Western blot - Anti-ALK-7 antibody - N-terminal (AB77051)

Lane 1:

Western blot - Anti-ALK-7 antibody - N-terminal (ab77051) at 1 µg/mL

Lane 2:

Western blot - Anti-ALK-7 antibody - N-terminal (ab77051) at 2 µg/mL

All lanes:

Human placenta lysate at 15 µg

Predicted band size: 54 kDa

Observed band size: 60 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ACVR1C. The exact immunogen used to generate this antibody is proprietary information.

Q8NER5

Specificity

ab77051 is predicted to have no cross-reactivity to ACVR1 or ACVR1B.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALK-7 also known as Activin receptor-like kinase 7 is a type I receptor serine/threonine kinase. It has a molecular mass of approximately 58 kDa. ALK-7 is primarily expressed in the central nervous system pancreatic islets and adipose tissue. This protein plays a mechanical role as a receptor that binds to ligands like Nodal which initiates signaling through phosphorylation events essential for cellular communication and regulation.
Biological function summary

ALK-7 participates in the regulation of metabolic processes. It functions by forming a receptor complex with type II receptors upon ligand binding transmitting signals that modulate cellular responses. ALK-7's signaling is important in maintaining glucose homeostasis and energy balance within tissues. Additionally the activity of ALK-7 influences the differentiation of neural cells and the development of adipose tissue illustrating its multifaceted biological roles.

Pathways

The signaling of ALK-7 integrates into the TGF-beta/Activin signaling pathway and the Nodal signaling pathway. Within these pathways it associates functionally with proteins such as SMAD2/3 which facilitate the transmission of extracellular signals to the nucleus resulting in gene expression changes. These pathways are significant for developmental processes and cellular metabolism regulation where ALK-7 contributes to signal transduction necessary for physiological adaptations.

ALK-7 has associations with metabolic syndromes like type 2 diabetes and obesity. Altered ALK-7 signaling affects insulin sensitivity and glucose metabolism linking it to the pathophysiology of these conditions. Furthermore its interaction with Nodal and other factors in related pathways suggests a potential therapeutic target for mitigating metabolic dysfunctions associated with these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed : 15531507, PubMed : 15150278). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (By similarity).
See full target information ACVR1C
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular metabolism 59:101465 PubMed35218946

2022

Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome.

Applications

Unspecified application

Species

Unspecified reactive species

Eva Rial-Pensado,Oscar Freire-Agulleiro,Marcos Ríos,Deng Fu Guo,Cristina Contreras,Patricia Seoane-Collazo,Sulay Tovar,Rubén Nogueiras,Carlos Diéguez,Kamal Rahmouni,Miguel López

Genes & development 26:2567-79 PubMed23152446

2012

Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandre R Colas,Wesley L McKeithan,Thomas J Cunningham,Paul J Bushway,Lana X Garmire,Gregg Duester,Shankar Subramaniam,Mark Mercola
View all publications
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Product promise

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