JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB229951

Anti-Allergin 1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Allergin 1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MILR1 aa 200-350.

View Alternative Names

C17orf60, MCA32, MILR1, Allergin-1, Allergy inhibitory receptor 1, Mast cell antigen 32, Mast cell immunoglobulin-like receptor 1, MCA-32

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Allergin 1 antibody (AB229951)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Allergin 1 antibody (AB229951)

HepG2 (human liver hepatocellular carcinoma cell line) cell stained for Allergin 1 (green) using ab229951 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Allergin 1 antibody (AB229951)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Allergin 1 antibody (AB229951)

Paraffin-embedded human liver cancer tissue stained for Allergin 1 using ab229951 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-Allergin 1 antibody (AB229951)
  • WB

Supplier Data

Western blot - Anti-Allergin 1 antibody (AB229951)

All lanes:

Western blot - Anti-Allergin 1 antibody (ab229951) at 1/1000 dilution

Lane 1:

Mouse brain lysate

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat anti-rabbit IgG at 1/10000 dilution

Predicted band size: 39 kDa

Observed band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MILR1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q7Z6M3

style
left-column

Complementary Products

Proteins & Peptides

AB277018

Recombinant Mouse Allergin 1 protein (Fc Chimera)

SDS-PAGE - Recombinant Mouse Allergin 1 protein (Fc Chimera) (AB277018)

  • 0
  • 0
Primary Antibodies

AB1791

Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade

Lab Essentials

ChIP - Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade (AB1791)

  • 5
  • 233
Primary Antibodies

AB151707

Anti-CD204 antibody [EPR7536]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-CD204 antibody [EPR7536] (AB151707)

  • 0
  • 0
Primary Antibodies

AB91606

Anti-Lysophospholipase 1/LPL-I antibody [EPR3667]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Lysophospholipase 1/LPL-I antibody [EPR3667] (AB91606)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Allergin-1 also known as allergine or epityphlon is a membrane protein expressed in myeloid cells particularly mast cells and basophils. The protein has a mass of approximately 50 kDa. Allergin-1 plays a role in signaling processes that regulate immune responses especially those involving allergen recognition and response. This protein contributes to modulating the activation and deactivation of these immune cells helping maintain a balanced immune reaction.
Biological function summary

Allergin-1 functions as an inhibitory receptor on myeloid cells. It forms part of a complex with other signaling proteins to suppress excessive immune responses that can lead to allergic reactions. This modulation involves interacting with several intracellular signaling proteins which in turn influence the release of mediators that affect the immune response. Allergin-1 through its inhibitory actions helps prevent over-activation of immune pathways that can contribute to allergic inflammation.

Pathways

Allergin-1 is involved in immune regulatory pathways such as the Fc receptor signaling pathway. It interacts with proteins like Syk kinase and SH2-containing phosphatases contributing to the negative regulation of cell activation. These pathways are key in the immune system's ability to distinguish between harmful and benign stimuli playing a protective role against unwarranted inflammatory responses.

Allergin-1 has connections to allergic conditions such as asthma and atopic dermatitis. Allergin-1's ability to modulate immune cell activation can influence the severity and occurrence of these allergic diseases. The protein's interaction with other immune regulators such as SHIP1 demonstrates its importance in managing diseases where exaggerated immune responses occur. Understanding these connections is essential for developing therapeutic strategies aimed at treating allergic disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).
See full target information MILR1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in genetics 12:644451 PubMed34367233

2021

Circular RNA Circ_0013958 Functions as a Tumor Promoter in Ovarian Cancer by Regulating miR-637/PLXNB2 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yanfei Liang,Kaiyi Meng,Rui Qiu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com